Tbio SERPINE2 Glia-derived nexin

Protein Summary

Description

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P07093
• B2R6A4
• B4DIF2
• Q53S15
• Q5D0C4
• GDN

Gene Name

• SERPINE2

Ensembl ID

• ENST00000258405
• ENSP00000258405
• ENSG00000135919
• ENST00000409304
• ENSP00000386412
• ENST00000409840
• ENSP00000386969
• ENST00000447280
• ENSP00000415786

Symbol

• PI7
• PN1
• GDN
• PI7
• PN1
• PNI
• PI-7
• PN-1
• GDNPF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
biological process	0.96
PubMedID	0.95
small molecule perturbation	0.92
kinase perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Glia-derived Nexin

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Glia-derived Nexin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.26   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 418.26   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (139)

Explore Interacting Targets

1 – 10 of 139

• See Interactions on String-DB

PLAU

Tchem

Family:  Enzyme

Novelty:  0.0005322

p_int:  0.999940035

p_ni:  0.000059965

Score:  0.986

Data Source:  BioPlex,STRINGDB

KLK13

Tchem

Family:  Enzyme

Novelty:  0.01963129

p_int:  0.998192293

p_ni:  0.001699715

p_wrong:  0.000107992

Score:  0.602

Data Source:  BioPlex,STRINGDB

LCN6

Tbio

Novelty:  0.11406686

p_int:  0.99782487

p_ni:  0.00217513

Data Source:  BioPlex

RTN1

Tbio

Novelty:  0.01828064

p_int:  0.997065554

p_ni:  0.002709739

p_wrong:  0.000224707

Score:  0.177

Data Source:  BioPlex,STRINGDB

FURIN

Tchem

Family:  Enzyme

Novelty:  0.00055079

p_int:  0.994270975

p_ni:  0.005729009

p_wrong:  1.6e-8

Score:  0.256

Data Source:  BioPlex,STRINGDB

NAT8B

Tbio

Family:  Enzyme

p_int:  0.988226686

p_ni:  0.011719687

p_wrong:  0.000053627

Data Source:  BioPlex

KCNE1

Tchem

Family:  IC

Novelty:  0.0015463

p_int:  0.987583369

p_ni:  0.01240454

p_wrong:  0.000012092

Data Source:  BioPlex

SCGB2A2

Tbio

Novelty:  0.01594053

p_int:  0.982835617

p_ni:  0.017164344

p_wrong:  3.9e-8

Score:  0.163

Data Source:  BioPlex,STRINGDB

C1QTNF9B

Tdark

Novelty:  0.7643008

p_int:  0.982315566

p_ni:  0.017636276

p_wrong:  0.000048158

Data Source:  BioPlex

SVOPL

Tdark

Novelty:  0.46448049

p_int:  0.957432669

p_ni:  0.04252543

p_wrong:  0.000041901

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

Common Pathway of Fibrin Clot Formation (R-HSA-140875)

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5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Reactome	Dissolution of Fibrin Clot	13 targets	R-HSA-75205
Reactome	Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Intrinsic Pathway of Fibrin Clot Formation	22 targets	R-HSA-140837

Name	Explore in Pharos	Explore in Source
Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Dissolution of Fibrin Clot	13 targets	R-HSA-75205
Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Hemostasis	666 targets	R-HSA-109582
Intrinsic Pathway of Fibrin Clot Formation	22 targets	R-HSA-140837

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (37)

Functions (4)

Components (8)

Processes (25)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
glycosaminoglycan binding	Inferred from Direct Assay (IDA)	BHF-UCL
heparin binding	Inferred from Direct Assay (IDA)	BHF-UCL
serine-type endopeptidase inhibitor activity	Inferred from Direct Assay (IDA)	BHF-UCL
signaling receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet-derived growth factor BB measurement	EFO_0008264	2	2	2		94.7
mean platelet volume	EFO_0004584	3	2	3		91.2
inflammatory biomarker measurement	EFO_0004872	1	1	0	1.3	88.5
body height	EFO_0004339	1	1	1		60.5
interleukin 10 measurement	EFO_0004750	1	1	1		5.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet-derived growth factor BB measurement	EFO_0008264	2		94.7
mean platelet volume	EFO_0004584	3		91.2
inflammatory biomarker measurement	EFO_0004872	0	1.3	88.5
body height	EFO_0004339	1		60.5
interleukin 10 measurement	EFO_0004750	1		5.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Developmental protein
Differentiation
Direct protein sequencing
Glycoprotein
Heparin-binding
Neurogenesis
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
body height
inflammatory biomarker measurement
interleukin 10 measurement
mean platelet volume
platelet-derived growth factor BB measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	serpin family E member 2	VGNC:10051	459980
Macaque	serpin family E member 2		707121
Mouse	serine (or cysteine) peptidase inhibitor, clade E, member 2	MGI:101780	20720
Rat	serpin family E member 2	RGD:3748	29366
Dog	serpin family E member 2	VGNC:46037	608930

Species	Name	OMA	EggNOG	Inparanoid
Chimp	serpin family E member 2
Macaque	serpin family E member 2
Mouse	serine (or cysteine) peptidase inhibitor, clade E, member 2
Rat	serpin family E member 2
Dog	serpin family E member 2

Publication Statistics

PubMed Score 418.26

PubMed score by year

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PubTator Score 813.37

PubTator score by year

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Related Publications

Text Mined References (90)

GeneRif Annotations (60)

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10

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PMID	Year	Title