P06881
Calcitonin gene-related peptide 1
Protein Summary
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
- ENST00000361010
- ENSP00000354286
- ENSG00000110680
- ENST00000486207
- ENSP00000417833
- CALC1
- CT
- KC
- PCT
- CGRP
- CALC1
- CGRP1
- CGRP-I
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
biological process | 0.99 | ||
chemical | 0.99 | ||
protein domain | 0.85 | ||
PubMedID | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16228.14 (req: < 5)
Gene RIFs: 443 (req: <= 3)
Antibodies: 1657 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16228.14 (req: >= 5)
Gene RIFs: 443 (req: > 3)
Antibodies: 1657 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 70
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3