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Tclin
P06881
Calcitonin gene-related peptide 1

Protein Summary
Description
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361010
  • ENSP00000354286
  • ENSG00000110680
  • ENST00000486207
  • ENSP00000417833

Symbol
  • CALC1
  • CT
  • KC
  • PCT
  • CGRP
  • CALC1
  • CGRP1
  • CGRP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.99
chemical
0.99
protein domain
0.85
PubMedID
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15332.65   (req: < 5)
Gene RIFs: 345   (req: <= 3)
Antibodies: 1657   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15332.65   (req: >= 5)
Gene RIFs: 345   (req: > 3)
Antibodies: 1657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (286)
PHF1
Tbio
Family:  Epigenetic
Novelty:  0.00430297
p_int:  0.999635156
p_ni:  0.000152635
p_wrong:  0.000212209
Data Source:  BioPlex
DCAF6
Tbio
Novelty:  0.01269552
p_int:  0.986635637
p_ni:  0.013364363
Data Source:  BioPlex
GIP
Tbio
Novelty:  0.0007219
p_int:  0.970012506
p_ni:  0.029987236
p_wrong:  2.58e-7
Score:  0.942
Data Source:  BioPlex,STRINGDB
CALCB
Tclin
Novelty:  0.02069808
p_int:  0.959087989
p_ni:  8e-9
p_wrong:  0.040912003
Score:  0.909
Data Source:  BioPlex,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.931435932
p_ni:  0.068564068
Data Source:  BioPlex
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
p_int:  0.928162743
p_ni:  0.000860859
p_wrong:  0.070976398
Data Source:  BioPlex
CALCRL
Tclin
Family:  GPCR
Novelty:  0.00568602
Score:  0.995
Data Source:  Reactome,STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.992
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.991
Data Source:  STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
Score:  0.991
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
11
14
44
3.6
99.9
vitamin D measurement
11
14
44
3.6
99.9
vitamin D deficiency
1
1
2
80.8
vitamin D deficiency
1
1
2
80.8
BMI-adjusted hip circumference
1
2
4
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
44
3.6
99.9
vitamin D measurement
44
3.6
99.9
vitamin D deficiency
2
80.8
vitamin D deficiency
2
80.8
BMI-adjusted hip circumference
4
66.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2151253
12310
Rat
RGD:2254
24241
Dog
calcitonin receptor-stimulating peptide 3
100187714
Horse
calcitonin-related polypeptide alpha
100033906
Cow
calcitonin related polypeptide beta
514876
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
calcitonin receptor-stimulating peptide 3
Horse
calcitonin-related polypeptide alpha
Cow
calcitonin related polypeptide beta
Publication Statistics
PubMed Score 15332.65
PubMed score by year
PubTator Score 3544.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title