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Tclin
P06881
Calcitonin gene-related peptide 1

Protein Summary
Description
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361010
  • ENSP00000354286
  • ENSG00000110680
  • ENST00000486207
  • ENSP00000417833

Symbol
  • CALC1
  • CT
  • KC
  • PCT
  • CGRP
  • CALC1
  • CGRP1
  • CGRP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.99
chemical
0.99
protein domain
0.85
PubMedID
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16228.14   (req: < 5)
Gene RIFs: 345   (req: <= 3)
Antibodies: 1657   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16228.14   (req: >= 5)
Gene RIFs: 345   (req: > 3)
Antibodies: 1657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3