Tchem KLK1 Kallikrein-1

Protein Summary

Description

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P06870
• Q66US9
• Q86U61
• Q8TCV8
• Q9BS53
• Q9NQU4
• Q9UD19
• Q9UMJ1

Gene Name

• KLK1

Ensembl ID

• ENST00000301420
• ENSP00000301420
• ENSG00000167748

Symbol

• hK1
• KLKR
• Klk6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.71
disease	0.7
cellular component	0.68
chemical	0.6
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Kallikrein-1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Kallikrein-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.63   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 400   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 522.63   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1