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Tbio
CRH
Corticoliberin

Protein Summary
Description
Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expresse ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276571
  • ENSP00000276571
  • ENSG00000147571

Symbol
  • CRF
  • CRH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.94
chemical
0.89
disease
0.69
gene perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5892.11   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 507   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5892.11   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 507   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (42)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene expression (Transcription)
Gene Ontology Terms (60)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (276)
1 – 10 of 276
UBR1
Tbio
Family: Enzyme
Novelty: 0.00742688
p_int: 0.983391919
p_ni: 0.016608081
Score: 0.187
Data Source: BioPlex,STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00229703
p_int: 0.825752109
p_ni: 0.16124927
p_wrong: 0.012998621
Score: 0.319
Data Source: BioPlex,STRINGDB
CRHR2
Tbio
Family: GPCR
Novelty: 0.00324955
Score: 0.999
Data Source: Reactome,STRINGDB
CRHR1
Tclin
Family: GPCR
Novelty: 0.00121307
Score: 0.999
Data Source: Reactome,STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.997
Data Source: STRINGDB
CRHBP
Tbio
Novelty: 0.00918779
Score: 0.996
Data Source: Reactome,STRINGDB
UCN
Tbio
Novelty: 0.00171727
Score: 0.993
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.0001163
Score: 0.99
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00011983
Score: 0.985
Data Source: STRINGDB
MC4R
Tclin
Family: GPCR
Novelty: 0.00104053
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  5892.11

PubMed score by year
PubTator Score  5424.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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