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Tchem
ITGAV
Integrin alpha-V

Protein Summary
Description
The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261023
  • ENSP00000261023
  • ENSG00000138448
  • ENST00000374907
  • ENSP00000364042
  • ENST00000433736
  • ENSP00000404291

Symbol
  • MSK8
  • VNRA
  • VTNR
  • CD51
  • MSK8
  • VNRA
  • VTNR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
molecular function
1
biological process
0.99
transcription factor perturbation
0.97
PubMedID
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.76   (req: < 5)
Gene RIFs: 419   (req: <= 3)
Antibodies: 1333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.76   (req: >= 5)
Gene RIFs: 419   (req: > 3)
Antibodies: 1333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
47.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
47.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha V
VGNC:2706
459807
Macaque
integrin subunit alpha V
707756
Mouse
MGI:96608
16410
Rat
RGD:1310613
296456
Dog
integrin subunit alpha V
VGNC:42134
488437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha V
Macaque
integrin subunit alpha V
Mouse
Rat
Dog
integrin subunit alpha V
Protein Structure (23 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06756-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (73)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Axon guidance
Cell surface interactions at the vascular wall
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (72)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (348)
1 – 10 of 348
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.959201964
p_ni: 0.040798036
Data Source: BioPlex
TNFSF13B
Tclin
Novelty: 0.00069885
p_int: 0.953426402
p_ni: 0.046573598
Data Source: BioPlex
SUSD4
Tbio
Novelty: 0.22201938
p_int: 0.950479416
p_ni: 0.049520584
Data Source: BioPlex
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.946460838
p_ni: 0.053539162
Data Source: BioPlex
LYZL2
Tdark
Family: Enzyme
Novelty: 0.50542161
p_int: 0.942146615
p_ni: 0.057853385
Data Source: BioPlex
NAAA
Tchem
Family: Enzyme
Novelty: 0.00368876
p_int: 0.938220644
p_ni: 0.061779356
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.9352497
p_ni: 0.0647503
Data Source: BioPlex
ST3GAL1
Tchem
Family: Enzyme
Novelty: 0.01236776
p_int: 0.927776674
p_ni: 0.072223326
Score: 0.154
Data Source: BioPlex,STRINGDB
CST9L
Tdark
Novelty: 0.21941207
p_int: 0.917535624
p_ni: 0.082464376
Data Source: BioPlex
GGH
Tchem
Family: Enzyme
Novelty: 0.00258239
p_int: 0.916876514
p_ni: 0.083123486
Score: 0.173
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  588.76

PubMed score by year
PubTator Score  548.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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