Tchem ITGAV Integrin alpha-V

Protein Summary

Description

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P06756
• A0AV67
• B0LPF4
• B7Z883
• B7ZLX0
• D3DPG8
• E7EWZ6
• Q53SK4
• Q59EB7
• Q6LD15

Gene Name

• ITGAV

Ensembl ID

• ENST00000261023
• ENSP00000261023
• ENSG00000138448
• ENST00000374907
• ENSP00000364042
• ENST00000433736
• ENSP00000404291

Symbol

• MSK8
• VNRA
• VTNR
• CD51
• MSK8
• VNRA
• VTNR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
molecular function	1
biological process	0.99
transcription factor perturbation	0.97
PubMedID	0.95

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.43   (req: < 5)

Gene RIFs: 419   (req: <= 3)

Antibodies: 1333   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.43   (req: >= 5)

Gene RIFs: 419   (req: > 3)

Antibodies: 1333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (30)

Explore Active Ligands

1 – 10 of 30

MK-0429

ITGAVTchem

pIC50 : 7.1

CHEMBL474902

ITGAVTchem

pIC50 : 8.3

CHEMBL550802

ITGAVTchem

pIC50 : 8.1

CHEMBL558130

ITGAVTchem

pIC50 : 7.96

CHEMBL471675

ITGAVTchem

pIC50 : 7.85

CHEMBL558917

ITGAVTchem

pIC50 : 7.72

CHEMBL562067

ITGAVTchem

pIC50 : 7.62

(R)-3-benzamido-2-(2-iodophenylsulfonamido)propanoic acid

ITGAVTchem

pIC50 : 7.6

CHEMBL560272

ITGAVTchem

pIC50 : 7.5

CHEMBL554267

ITGAVTchem

pIC50 : 7.39

Protein-Protein Interactions (348)

Explore Interacting Targets

1 – 10 of 348

• See Interactions on String-DB

PSCA

Tbio

Novelty:  0.00323778

p_int:  0.959201964

p_ni:  0.040798036

Data Source:  BioPlex

TNFSF13B

Tclin

Novelty:  0.00069885

p_int:  0.953426402

p_ni:  0.046573598

Data Source:  BioPlex

SUSD4

Tbio

Novelty:  0.22201938

p_int:  0.950479416

p_ni:  0.049520584

Data Source:  BioPlex

TAZ

Tbio

Novelty:  0.00372301

p_int:  0.946460838

p_ni:  0.053539162

Data Source:  BioPlex

LYZL2

Tdark

Family:  Enzyme

Novelty:  0.50542161

p_int:  0.942146615

p_ni:  0.057853385

Data Source:  BioPlex

NAAA

Tchem

Family:  Enzyme

Novelty:  0.00368876

p_int:  0.938220644

p_ni:  0.061779356

Data Source:  BioPlex

DEFA1

Tbio

Novelty:  0.01027492

p_int:  0.9352497

p_ni:  0.0647503

Data Source:  BioPlex

ST3GAL1

Tchem

Family:  Enzyme

Novelty:  0.01236776

p_int:  0.927776674

p_ni:  0.072223326

Score:  0.154

Data Source:  BioPlex,STRINGDB

CST9L

Tdark

Novelty:  0.21941207

p_int:  0.917535624

p_ni:  0.082464376

Data Source:  BioPlex

GGH

Tchem

Family:  Enzyme

Novelty:  0.00258239

p_int:  0.916876514

p_ni:  0.083123486

Score:  0.173

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (11)

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Upstream (5)

Downstream (6)

1 – 5 of 5

ITGA2B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  11

1: PI3K-Akt signaling pathway

2: ECM-receptor interaction

3: Focal adhesion

4: Dilated cardiomyopathy (DCM)

more:  7 more common pathways

ITGB3

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  13

1: PI3K-Akt signaling pathway

2: ECM-receptor interaction

3: Focal adhesion

4: Dilated cardiomyopathy (DCM)

more:  9 more common pathways

ITGB1

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  13

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  9 more common pathways

ITGB7

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  9

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  5 more common pathways

ITGA4

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  9

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  5 more common pathways

Pathways (73)

Reactome (26)

KEGG (16)

PathwayCommons (17)

WikiPathways (14)

Adaptive Immune System (R-HSA-1280218)

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5

1 – 5 of 26

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Axon guidance	533 targets	R-HSA-422475
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (72)

Functions (12)

Components (22)

Processes (38)

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10

1 – 10 of 12

GO Term	Evidence	Assigned by
extracellular matrix binding	Inferred from Direct Assay (IDA)	UniProtKB
extracellular matrix protein binding	Inferred from Direct Assay (IDA)	UniProtKB
fibronectin binding	Inferred from Direct Assay (IDA)	UniProtKB
protease binding	Inferred from Direct Assay (IDA)	UniProtKB
voltage-gated calcium channel activity	Inferred from Direct Assay (IDA)	UniProtKB
integrin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
transforming growth factor beta binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
coreceptor activity	Traceable Author Statement (TAS)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
opsonin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
FEV/FEC ratio	EFO_0004713	1	1	1		60.2
inflammatory bowel disease	EFO_0003767	1	1	0	1.1	24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
FEV/FEC ratio	EFO_0004713	1		60.2
inflammatory bowel disease	EFO_0003767	0	1.1	24.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
FEV/FEC ratio
inflammatory bowel disease

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha V	VGNC:2706	459807
Macaque	integrin subunit alpha V		707756
Mouse	integrin alpha V	MGI:96608	16410
Rat	integrin subunit alpha V	RGD:1310613	296456
Dog	integrin subunit alpha V	VGNC:42134	488437

Species	Name	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha V
Macaque	integrin subunit alpha V
Mouse	integrin alpha V
Rat	integrin subunit alpha V
Dog	integrin subunit alpha V

Publication Statistics

PubMed Score 591.43

PubMed score by year

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PubTator Score 548.29

PubTator score by year

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Related Publications

Text Mined References (541)

GeneRif Annotations (419)

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PMID	Year	Title