Protein Summary
The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to ...more
- ENST00000261023
- ENSP00000261023
- ENSG00000138448
- ENST00000374907
- ENSP00000364042
- ENST00000433736
- ENSP00000404291
- MSK8
- VNRA
- VTNR
- CD51
- MSK8
- VNRA
- VTNR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
molecular function | 1 | ||
biological process | 0.99 | ||
transcription factor perturbation | 0.97 | ||
PubMedID | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 591.43 (req: < 5)
Gene RIFs: 419 (req: <= 3)
Antibodies: 1333 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 591.43 (req: >= 5)
Gene RIFs: 419 (req: > 3)
Antibodies: 1333 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 50
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 30
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (30)
Protein-Protein Interactions (348)
LYZL2
Family: Enzyme
Novelty: 0.50542161
p_int: 0.942146615
p_ni: 0.057853385
Data Source: BioPlex
NAAA
Family: Enzyme
Novelty: 0.00368876
p_int: 0.938220644
p_ni: 0.061779356
Data Source: BioPlex
ST3GAL1
Family: Enzyme
Novelty: 0.01236776
p_int: 0.927776674
p_ni: 0.072223326
Score: 0.154
Data Source: BioPlex,STRINGDB
GGH
Family: Enzyme
Novelty: 0.00258239
p_int: 0.916876514
p_ni: 0.083123486
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (11)
Upstream (5)
Downstream (6)
1 – 5 of 5
Pathways (73)
Reactome (26)
KEGG (16)
PathwayCommons (17)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Axon guidance | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Axon guidance | ||||
Cell surface interactions at the vascular wall | ||||
Class I MHC mediated antigen processing & presentation | ||||
Viral Interactions (0)
Gene Ontology Terms (72)
Functions (12)
Components (22)
Processes (38)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 1 | 1 | 60.2 | |||||
1 | 1 | 0 | 1.1 | 24.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 60.2 | |||||
0 | 1.1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha V | VGNC:2706 | 459807 | |||||
Macaque | integrin subunit alpha V | 707756 | ||||||
Mouse | MGI:96608 | 16410 | ||||||
Rat | RGD:1310613 | 296456 | ||||||
Dog | integrin subunit alpha V | VGNC:42134 | 488437 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | integrin subunit alpha V | |||||
Macaque | integrin subunit alpha V | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha V | |||||
Publication Statistics
PubMed Score 591.43
PubMed score by year
PubTator Score 548.29
PubTator score by year
Related Publications
Text Mined References (541)
GeneRif Annotations (419)
Items per page:
0 of 0
PMID | Year | Title |
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