You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TPM3
Tropomyosin alpha-3 chain

Protein Summary
Description
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternativ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302206
  • ENSP00000307712
  • ENSG00000143549
  • ENST00000323144
  • ENSP00000357518
  • ENST00000328159
  • ENSP00000357520
  • ENST00000330188
  • ENSP00000339035
  • ENST00000368530
  • ENSP00000357516
  • ENST00000368531
  • ENSP00000357517
  • ENST00000368533
  • ENSP00000357521

Symbol
  • TM3
  • TM5
  • TRK
  • CFTD
  • NEM1
  • TM-5
  • TM30
  • CAPM1
  • TM30nm
  • TPM3nu
  • TPMsk3
  • hscp30
  • HEL-189
  • HEL-S-82p
  • OK/SW-cl.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.94
transcription factor perturbation
0.94
kinase perturbation
0.93
PubMedID
0.8
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 843.8   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 843.8   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
6
6
92
triglyceride measurement
3
3
3
86.5
mean corpuscular volume
3
3
3
83.9
mathematical ability
2
1
2
77.1
mean platelet volume
3
1
3
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
92
triglyceride measurement
3
86.5
mean corpuscular volume
3
83.9
mathematical ability
2
77.1
mean platelet volume
3
74.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tropomyosin 3
VGNC:1697
458000
Macaque
tropomyosin 3
716336
Mouse
MGI:1890149
59069
Horse
tropomyosin 3
VGNC:24435
100056751
Cow
tropomyosin 3
VGNC:36253
497019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tropomyosin 3
Macaque
tropomyosin 3
Mouse
Horse
tropomyosin 3
Cow
tropomyosin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P06753-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Striated Muscle Contraction
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (212)
1 – 10 of 212
IMP3
Tbio
Novelty:  0.42681287
p_int:  0.999935503
p_ni:  0.000064497
Score:  0.485
Data Source:  BioPlex,STRINGDB
CALCOCO1
Tbio
Novelty:  0.17497928
p_int:  0.986998389
p_ni:  0.013001591
p_wrong:  2e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
p_int:  0.9816355
p_ni:  0.018346387
p_wrong:  0.000018112
Score:  0.39
Data Source:  BioPlex,STRINGDB
METTL2B
Tbio
Family:  Enzyme
Novelty:  0.05619551
p_int:  0.97483563
p_ni:  0.009214773
p_wrong:  0.015949598
Score:  0.351
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.888219823
p_ni:  0.111780177
Data Source:  BioPlex
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.756754752
p_ni:  0.243245248
Score:  0.197
Data Source:  BioPlex,STRINGDB
ACTA1
Tbio
Novelty:  0.00111813
Score:  0.992
Data Source:  STRINGDB
TPM1
Tbio
Novelty:  0.00261206
Score:  0.986
Data Source:  STRINGDB
TMOD1
Tbio
Novelty:  0.01142927
Score:  0.985
Data Source:  STRINGDB
ACTG2
Tbio
Novelty:  0.00304944
Score:  0.985
Data Source:  STRINGDB
Publication Statistics
PubMed Score  843.80

PubMed score by year
PubTator Score  549.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: