Tbio NPM1 Nucleophosmin

Protein Summary

Description

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P06748
• A8K3N7
• B5BU00
• D3DQL6
• P08693
• Q12826
• Q13440
• Q13441
• Q14115
• Q5EU94
• Q5EU95
• Q5EU96
• Q5EU97
• Q5EU98
• Q5EU99
• Q6V962
• Q8WTW5
• Q96AT6
• Q96DC4
• Q96EA5
• Q9BYG9
• Q9UDJ7
• NPM

Gene Name

• NPM1

Ensembl ID

• ENST00000296930
• ENSP00000296930
• ENSG00000181163
• ENST00000351986
• ENSP00000341168
• ENST00000393820
• ENSP00000377408
• ENST00000517671
• ENSP00000428755

Symbol

• NPM
• B23
• NPM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
drug perturbation	1
hub protein	1
interacting protein	1
kinase perturbation	0.99

Protein Classes

PANTHER Classes

Protein / Chaperone / Nucleophosmin

DTO Classes

Protein / Chaperone / Nucleophosmin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2301.67   (req: < 5)

Gene RIFs: 641   (req: <= 3)

Antibodies: 1163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2301.67   (req: >= 5)

Gene RIFs: 641   (req: > 3)

Antibodies: 1163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0