Protein Summary
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylatio ...more
- ENST00000296930
- ENSP00000296930
- ENSG00000181163
- ENST00000351986
- ENSP00000341168
- ENST00000393820
- ENSP00000377408
- ENST00000517671
- ENSP00000428755
- NPM
- B23
- NPM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
drug perturbation | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1878.45 (req: < 5)
Gene RIFs: 493 (req: <= 3)
Antibodies: 1163 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1878.45 (req: >= 5)
Gene RIFs: 493 (req: > 3)
Antibodies: 1163 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 52
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (455)
USP36
Family: Enzyme
Novelty: 0.02779727
p_int: 0.999998455
p_ni: 0.000001545
Score: 0.538
Data Source: BioPlex,STRINGDB
NPM2
Novelty: 0.03674672
p_int: 0.999923046
p_ni: 0.000076954
Score: 0.605
Data Source: BioPlex,STRINGDB
RPP25
Family: Enzyme
Novelty: 0.07178063
p_int: 0.998624864
p_ni: 0.001375096
p_wrong: 4.1e-8
Score: 0.52
Data Source: BioPlex,STRINGDB
H2AFX
Novelty: 0.00048694
p_int: 0.998123878
p_ni: 0.001876122
Score: 0.953
Data Source: BioPlex,STRINGDB
RPP25L
Family: Enzyme
Novelty: 1.39761189
p_int: 0.997911688
p_ni: 0.001864232
p_wrong: 0.000224081
Score: 0.221
Data Source: BioPlex,STRINGDB
POP4
Family: Enzyme
Novelty: 0.01072287
p_int: 0.994801362
p_ni: 0.005198638
Score: 0.343
Data Source: BioPlex,STRINGDB
RPL36AL
Novelty: 0.09336423
p_int: 0.992819854
p_ni: 0.007174858
p_wrong: 0.000005288
Score: 0.272
Data Source: BioPlex,STRINGDB
RPP40
Family: Enzyme
Novelty: 0.05981624
p_int: 0.992184636
p_ni: 0.007813859
p_wrong: 0.000001505
Score: 0.59
Data Source: BioPlex,STRINGDB
NMNAT1
Family: Enzyme
Novelty: 0.01110899
p_int: 0.991369088
p_ni: 0.008630912
Data Source: BioPlex
RRP8
Family: Enzyme
Novelty: 0.04922797
p_int: 0.991107802
p_ni: 0.008892198
Score: 0.46
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (26)
Reactome (23)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Chromosome Maintenance | ||||
Reactome | Deposition of new CENPA-containing nucleosomes at the centromere | ||||
Reactome | Disease | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Chromosome Maintenance | ||||
Deposition of new CENPA-containing nucleosomes at the centromere | ||||
Disease | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (64)
Functions (16)
Components (12)
Processes (36)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 2 | 2 | 2 | 82.4 | |||||
BMI-adjusted hip circumference | 2 | 3 | 3 | 64.9 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 42.3 | |||||
FEV/FEC ratio | 1 | 1 | 1 | 34.8 | |||||
mathematical ability | 2 | 2 | 2 | 28 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 2 | 82.4 | |||||
BMI-adjusted hip circumference | 3 | 64.9 | |||||
comparative body size at age 10, self-reported | 1 | 42.3 | |||||
FEV/FEC ratio | 1 | 34.8 | |||||
mathematical ability | 2 | 28 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:106184 | 18148 | ||||||
Rat | RGD:3192 | 25498 | ||||||
Dog | nucleophosmin 1 | 479292 | ||||||
Horse | nucleophosmin 1 | VGNC:20841 | 100059112 | |||||
Cow | nucleophosmin 1 | 614028 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | nucleophosmin 1 | |||||
Horse | nucleophosmin 1 | |||||
Cow | nucleophosmin 1 | |||||
Publication Statistics
PubMed Score 1878.45
PubMed score by year
PubTator Score 1203.81
PubTator score by year
Related Publications
Text Mined References (609)
GeneRif Annotations (493)
Items per page:
0 of 0
PMID | Year | Title |
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