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Tbio
NPM1
Nucleophosmin

Protein Classes
Protein Summary
Description
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylatio ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
drug perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
0.99


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1814.11   (req: < 5)
Gene RIFs: 493   (req: <= 3)
Antibodies: 1163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1814.11   (req: >= 5)
Gene RIFs: 493   (req: > 3)
Antibodies: 1163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
59.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
59.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106184
18148
Rat
RGD:3192
25498
Dog
nucleophosmin 1
479292
Horse
nucleophosmin 1
VGNC:20841
100059112
Cow
nucleophosmin 1
614028
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
nucleophosmin 1
Horse
nucleophosmin 1
Cow
nucleophosmin 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06748-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
Deposition of new CENPA-containing nucleosomes at the centromere
Reactome
Disease
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromosome Maintenance
Deposition of new CENPA-containing nucleosomes at the centromere
Disease
Gene expression (Transcription)
Gene Ontology Terms (64)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (455)
1 – 10 of 455
USP36
Tbio
Family: Enzyme
Novelty: 0.02779727
p_int: 0.999998455
p_ni: 0.000001545
Score: 0.538
Data Source: BioPlex,STRINGDB
NPM2
Tbio
Novelty: 0.03674672
p_int: 0.999923046
p_ni: 0.000076954
Score: 0.605
Data Source: BioPlex,STRINGDB
RPP25
Tbio
Family: Enzyme
Novelty: 0.07178063
p_int: 0.998624864
p_ni: 0.001375096
p_wrong: 4.1e-8
Score: 0.52
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.998123878
p_ni: 0.001876122
Score: 0.953
Data Source: BioPlex,STRINGDB
RPP25L
Tdark
Family: Enzyme
Novelty: 1.39761189
p_int: 0.997911688
p_ni: 0.001864232
p_wrong: 0.000224081
Score: 0.221
Data Source: BioPlex,STRINGDB
POP4
Tbio
Family: Enzyme
Novelty: 0.01072287
p_int: 0.994801362
p_ni: 0.005198638
Score: 0.343
Data Source: BioPlex,STRINGDB
RPL36AL
Tbio
Novelty: 0.09336423
p_int: 0.992819854
p_ni: 0.007174858
p_wrong: 0.000005288
Score: 0.272
Data Source: BioPlex,STRINGDB
RPP40
Tbio
Family: Enzyme
Novelty: 0.05981624
p_int: 0.992184636
p_ni: 0.007813859
p_wrong: 0.000001505
Score: 0.59
Data Source: BioPlex,STRINGDB
NMNAT1
Tbio
Family: Enzyme
Novelty: 0.01110899
p_int: 0.991369088
p_ni: 0.008630912
Data Source: BioPlex
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.991107802
p_ni: 0.008892198
Score: 0.46
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1814.11

PubMed score by year
PubTator Score  1203.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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