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Tbio
GPI
Glucose-6-phosphate isomerase

Protein Classes
Protein Summary
Description
Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356487
  • ENSP00000348877
  • ENSG00000105220
  • ENST00000588991
  • ENSP00000465858
  • ENST00000644934
  • ENSP00000493517

Symbol
  • AMF
  • NLK
  • PGI
  • PHI
  • GNPI
  • SA36
  • SA-36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.96
PubMedID
0.94
protein complex
0.9
interacting protein
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1013.36   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 623   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1013.36   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 623   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
54.4
electrocardiography
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
54.4
electrocardiography
1
15.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucose-6-phosphate isomerase
VGNC:2548
100612813
Macaque
glucose-6-phosphate isomerase
717933
Mouse
MGI:95797
14751
Rat
RGD:2727
292804
Dog
glucose-6-phosphate isomerase
VGNC:41381
611942
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucose-6-phosphate isomerase
Macaque
glucose-6-phosphate isomerase
Mouse
Rat
Dog
glucose-6-phosphate isomerase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06744-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Gluconeogenesis
Glucose metabolism
Glycolysis
Gene Ontology Terms (43)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (243)
1 – 10 of 243
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.999
Data Source:  STRINGDB
PGM1
Tbio
Family:  Enzyme
Novelty:  0.00163947
Score:  0.997
Data Source:  STRINGDB
G6PD
Tchem
Family:  Enzyme
Novelty:  0.00064455
Score:  0.994
Data Source:  STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.993
Data Source:  STRINGDB
PFKM
Tbio
Family:  Kinase
Novelty:  0.00217816
Score:  0.993
Data Source:  STRINGDB
H6PD
Tbio
Novelty:  0.00366637
Score:  0.991
Data Source:  STRINGDB
PFKL
Tbio
Family:  Kinase
Novelty:  0.00586306
Score:  0.991
Data Source:  STRINGDB
TALDO1
Tbio
Family:  Enzyme
Novelty:  0.00208619
Score:  0.991
Data Source:  STRINGDB
PFKP
Tbio
Family:  Kinase
Novelty:  0.00808684
Score:  0.991
Data Source:  STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.99
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1013.36

PubMed score by year
PubTator Score  2034.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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