Tbio GPI Glucose-6-phosphate isomerase

Protein Summary

Description

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• P06744
• B4DG39
• Q9BRD3
• Q9BSK5
• Q9UHE6
• GPI

Gene Name

• GPI

Ensembl ID

• ENST00000356487
• ENSP00000348877
• ENSG00000105220
• ENST00000588991
• ENSP00000465858
• ENST00000644934
• ENSP00000493517

Symbol

• AMF
• NLK
• PGI
• PHI
• GNPI
• SA36
• SA-36

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
kinase perturbation	0.96
PubMedID	0.94
protein complex	0.9
interacting protein	0.86

Protein Classes

PANTHER Classes

Protein / Isomerase / Glucose-6-phosphate Isomerase

DTO Classes

Protein / Enzyme / Isomerase / Glucose-6-phosphate Isomerase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1120.72   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 623   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1120.72   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 623   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0