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Tbio
GPI
Glucose-6-phosphate isomerase

Protein Classes
Protein Summary
Description
Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356487
  • ENSP00000348877
  • ENSG00000105220
  • ENST00000588991
  • ENSP00000465858
  • ENST00000644934
  • ENSP00000493517

Symbol
  • AMF
  • NLK
  • PGI
  • PHI
  • GNPI
  • SA36
  • SA-36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
kinase perturbation
0.96
PubMedID
0.94
protein complex
0.9
interacting protein
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1334.11   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 623   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1334.11   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 623   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Gluconeogenesis
Glucose metabolism
Glycolysis
Gene Ontology Terms (43)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (243)
1 – 10 of 243
TPI1
Tbio
Family: Enzyme
Novelty: 0.00117277
Score: 0.999
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00195415
Score: 0.997
Data Source: STRINGDB
G6PD
Tchem
Family: Enzyme
Novelty: 0.00088391
Score: 0.994
Data Source: STRINGDB
MPI
Tchem
Family: Enzyme
Novelty: 0.00966817
Score: 0.993
Data Source: STRINGDB
PFKM
Tbio
Family: Kinase
Novelty: 0.00334458
Score: 0.993
Data Source: STRINGDB
H6PD
Tbio
Novelty: 0.00498038
Score: 0.991
Data Source: STRINGDB
PFKL
Tbio
Family: Kinase
Novelty: 0.00824192
Score: 0.991
Data Source: STRINGDB
TALDO1
Tbio
Family: Enzyme
Novelty: 0.00254889
Score: 0.991
Data Source: STRINGDB
PFKP
Tbio
Family: Kinase
Novelty: 0.0112356
Score: 0.991
Data Source: STRINGDB
TKT
Tchem
Family: Enzyme
Novelty: 0.0027011
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  1334.11

PubMed score by year
PubTator Score  2034.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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