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Tchem
PYGL
Glycogen phosphorylase, liver form

Protein Summary
Description
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glyc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216392
  • ENSP00000216392
  • ENSG00000100504
  • ENST00000544180
  • ENSP00000443787

Symbol
  • GSD6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
transcription factor perturbation
0.97
PubMedID
0.94
virus perturbation
0.88
gene perturbation
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.16   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.16   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 372
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Glycogen breakdown (glycogenolysis) (R-HSA-70221)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Immune System
Innate Immune System
Metabolism
Gene Ontology Terms (25)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (140)
1 – 10 of 140
ZFP41
Tdark
Family: TF
Novelty: 11
p_int: 0.994503783
p_ni: 0.005496217
Data Source: BioPlex
DCAF4L2
Tdark
Novelty: 2.65263158
p_int: 0.959711754
p_ni: 0.040288246
Score: 0.54
Data Source: BioPlex,STRINGDB
NTF3
Tbio
Novelty: 0.00076486
p_int: 0.831239695
p_ni: 0.168760306
Score: 0.519
Data Source: BioPlex,STRINGDB
GBE1
Tbio
Family: Enzyme
Novelty: 0.00472598
Score: 0.994
Data Source: STRINGDB
AGL
Tbio
Novelty: 0.00236651
Score: 0.992
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00195415
Score: 0.98
Data Source: STRINGDB
PHKG2
Tchem
Family: Kinase
Novelty: 0.09845673
Score: 0.97
Data Source: Reactome,STRINGDB
UGP2
Tbio
Family: Enzyme
Novelty: 0.00283311
Score: 0.967
Data Source: STRINGDB
PYGB
Tbio
Family: Enzyme
Novelty: 0.0023816
Score: 0.962
Data Source: STRINGDB
PYGM
Tchem
Family: Enzyme
Novelty: 0.00573817
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.16

PubMed score by year
PubTator Score  15.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer