FCER2
Low affinity immunoglobulin epsilon Fc receptor
Protein Summary
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
- ENST00000346664
- ENSP00000264072
- ENSG00000104921
- ENST00000597921
- ENSP00000471974
- CD23A
- CLEC4J
- FCE2
- IGEBF
- CD23
- FCE2
- CD23A
- IGEBF
- CLEC4J
- BLAST-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.83 | ||
cell type or tissue | 0.65 | ||
protein domain | 0.58 | ||
gene perturbation | 0.56 | ||
tissue sample | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 450.4 (req: < 5)
Gene RIFs: 104 (req: <= 3)
Antibodies: 1493 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 450.4 (req: >= 5)
Gene RIFs: 104 (req: > 3)
Antibodies: 1493 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 45
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0