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Tchem
FCER2
Low affinity immunoglobulin epsilon Fc receptor

Protein Summary
Description
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346664
  • ENSP00000264072
  • ENSG00000104921
  • ENST00000597921
  • ENSP00000471974

Symbol
  • CD23A
  • CLEC4J
  • FCE2
  • IGEBF
  • CD23
  • FCE2
  • CD23A
  • IGEBF
  • CLEC4J
  • BLAST-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
cell type or tissue
0.65
protein domain
0.58
gene perturbation
0.56
tissue sample
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.4   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 1493   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.4   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 1493   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0