Tchem ENO1 Alpha-enolase

Protein Classes

PANTHER Classes

Protein / Lyase / Alpha-enolase

DTO Classes

Protein / Enzyme / Lyase / Alpha-enolase

Protein Summary

Description

Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P06733
• B2RD59
• P22712
• Q16704
• Q4TUS4
• Q53FT9
• Q53HR3
• Q658M5
• Q6GMP2
• Q71V37
• Q7Z3V6
• Q8WU71
• Q96GV1
• Q9BT62
• Q9UCH6
• Q9UM55

Gene Name

• ENO1

Ensembl ID

• ENST00000234590
• ENSP00000234590
• ENSG00000074800
• ENST00000646539
• ENSP00000493526

Symbol

• ENO1L1
• MBPB1
• MPB1
• NNE
• PPH
• MPB1
• ENO1L1
• HEL-S-17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
protein complex	1
transcription factor binding site profile	0.99
transcription factor perturbation	0.99

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 905.04   (req: < 5)

Gene RIFs: 96   (req: <= 3)

Antibodies: 773   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 905.04   (req: >= 5)

Gene RIFs: 96   (req: > 3)

Antibodies: 773   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL3335790

ENO1Tchem Enzyme

IC50 : 6.24

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	enolase 1	VGNC:9863	457913
Mouse	enolase 1, alpha non-neuron	MGI:95393	13806
Rat	enolase 1	RGD:2553	24333
Horse	enolase 1		100051879
Cow	enolase 1		281141

Species	Name	OMA	EggNOG	Inparanoid
Chimp	enolase 1
Mouse	enolase 1, alpha non-neuron
Rat	enolase 1
Horse	enolase 1
Cow	enolase 1

Protein Structure (7 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06733-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (24)

Reactome (5)

KEGG (6)

PathwayCommons (9)

UniProt (1)

WikiPathways (3)

Gluconeogenesis (R-HSA-70263)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gluconeogenesis	34 targets	R-HSA-70263
Reactome	Glucose metabolism	92 targets	R-HSA-70326
Reactome	Glycolysis	72 targets	R-HSA-70171
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of carbohydrates	293 targets	R-HSA-71387

Name	Explore in Pharos	Explore in Source
Gluconeogenesis	34 targets	R-HSA-70263
Glucose metabolism	92 targets	R-HSA-70326
Glycolysis	72 targets	R-HSA-70171
Metabolism	2112 targets	R-HSA-1430728
Metabolism of carbohydrates	293 targets	R-HSA-71387

Gene Ontology Terms (30)

Functions (9)

Components (11)

Processes (10)

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Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
protein homodimerization activity	Inferred from Direct Assay (IDA)	CAFA
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	CAFA
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
GTPase binding	Inferred from Physical Interaction (IPI)	UniProtKB
phosphopyruvate hydratase activity	Inferred from Mutant Phenotype (IMP)	CAFA
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
magnesium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (333)

Explore Interacting Targets

1 – 10 of 333

• See Interactions on String-DB

ENO2

Tbio

Family: Enzyme

Novelty: 0.00016748

p_int: 0.999959942

p_ni: 0.000040058

Score: 0.963

Data Source: BioPlex,STRINGDB

ENO3

Tbio

Family: Enzyme

Novelty: 0.00322051

p_int: 0.999902403

p_ni: 0.000097597

Score: 0.962

Data Source: BioPlex,STRINGDB

TPI1

Tbio

Family: Enzyme

Novelty: 0.00074652

Score: 0.996

Data Source: STRINGDB

GAPDH

Tchem

Family: Enzyme

Novelty: 0.00005849

Score: 0.995

Data Source: STRINGDB

PKM

Tchem

Family: Kinase

Novelty: 0.00076567

Score: 0.993

Data Source: STRINGDB

PGAM1

Tbio

Family: Enzyme

Novelty: 0.0111272

Score: 0.993

Data Source: STRINGDB

PGK1

Tchem

Family: Kinase

Novelty: 0.00113494

Score: 0.991

Data Source: STRINGDB

GPI

Tbio

Family: Enzyme

Novelty: 0.00095404

Score: 0.99

Data Source: STRINGDB

PKLR

Tbio

Family: Kinase

Novelty: 0.00268398

Score: 0.984

Data Source: STRINGDB

PGAM2

Tbio

Family: Enzyme

Novelty: 0.02438933

Score: 0.978

Data Source: STRINGDB

Publication Statistics

PubMed Score  905.04

PubMed score by year

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PubTator Score  762.56

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative initiation
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
DNA-binding
Glycolysis
Isopeptide bond

MGI Phenotype Find Similar Targets

embryo phenotype
growth/size/body region phenotype
mortality/aging