Protein Summary
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes ha ...more
- ENST00000234590
- ENSP00000234590
- ENSG00000074800
- ENST00000646539
- ENSP00000493526
- ENO1L1
- MBPB1
- MPB1
- NNE
- PPH
- MPB1
- ENO1L1
- HEL-S-17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
protein complex | 1 | ||
transcription factor binding site profile | 0.99 | ||
transcription factor perturbation | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 918.07 (req: < 5)
Gene RIFs: 96 (req: <= 3)
Antibodies: 773 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 918.07 (req: >= 5)
Gene RIFs: 96 (req: > 3)
Antibodies: 773 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (333)
Nearest Tclin Targets
Pathways (24)
Reactome (5)
KEGG (6)
PathwayCommons (9)
UniProt (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gluconeogenesis | ||||
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gluconeogenesis | ||||
Glucose metabolism | ||||
Glycolysis | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (9)
Components (11)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 3 | 3 | 91.8 | |||||
platelet crit | 2 | 2 | 2 | 86.4 | |||||
myeloid white cell count | 2 | 2 | 2 | 82.2 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 49.5 | |||||
basophil count | 2 | 2 | 2 | 40.7 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 91.8 | |||||
platelet crit | 2 | 86.4 | |||||
myeloid white cell count | 2 | 82.2 | |||||
lymphocyte percentage of leukocytes | 1 | 49.5 | |||||
basophil count | 2 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | enolase 1 | VGNC:9863 | 457913 | |||||
Mouse | MGI:95393 | 13806 | ||||||
Rat | RGD:2553 | 24333 | ||||||
Horse | enolase 1 | 100051879 | ||||||
Cow | enolase 1 | 281141 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | enolase 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | enolase 1 | |||||
Cow | enolase 1 | |||||
Publication Statistics
PubMed Score 918.07
PubMed score by year
PubTator Score 762.56
PubTator score by year
Related Publications
Text Mined References (167)
GeneRif Annotations (96)
Items per page:
0 of 0
PMID | Year | Title |
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