Protein Classes
Protein Summary
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes ha ...more
- ENST00000234590
- ENSP00000234590
- ENSG00000074800
- ENST00000646539
- ENSP00000493526
- ENO1L1
- MBPB1
- MPB1
- NNE
- PPH
- MPB1
- ENO1L1
- HEL-S-17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
protein complex | 1 | ||
transcription factor binding site profile | 0.99 | ||
transcription factor perturbation | 0.99 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 707.86 (req: < 5)
Gene RIFs: 96 (req: <= 3)
Antibodies: 773 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 707.86 (req: >= 5)
Gene RIFs: 96 (req: > 3)
Antibodies: 773 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (24)
Reactome (5)
KEGG (6)
PathwayCommons (9)
UniProt (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gluconeogenesis | ||||
Reactome | Glucose metabolism | ||||
Reactome | Glycolysis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of carbohydrates | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gluconeogenesis | ||||
Glucose metabolism | ||||
Glycolysis | ||||
Metabolism | ||||
Metabolism of carbohydrates | ||||
Gene Ontology Terms (30)
Functions (9)
Components (11)
Processes (10)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (333)
1 – 10 of 333
ENO2
Family: Enzyme
Novelty: 0.00021254
p_int: 0.999959942
p_ni: 0.000040058
Score: 0.963
Data Source: BioPlex,STRINGDB
ENO3
Family: Enzyme
Novelty: 0.00432053
p_int: 0.999902403
p_ni: 0.000097597
Score: 0.962
Data Source: BioPlex,STRINGDB
TPI1
Family: Enzyme
Novelty: 0.00117277
Score: 0.996
Data Source: STRINGDB
GAPDH
Family: Enzyme
Novelty: 0.00019506
Score: 0.995
Data Source: STRINGDB
PKM
Family: Kinase
Novelty: 0.00066016
Score: 0.993
Data Source: STRINGDB
PGAM1
Family: Enzyme
Novelty: 0.0137131
Score: 0.993
Data Source: STRINGDB
PGK1
Family: Kinase
Novelty: 0.00144192
Score: 0.991
Data Source: STRINGDB
GPI
Family: Enzyme
Novelty: 0.00073017
Score: 0.99
Data Source: STRINGDB
PKLR
Family: Kinase
Novelty: 0.00411221
Score: 0.984
Data Source: STRINGDB
PGAM2
Family: Enzyme
Novelty: 0.02989704
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score 707.86
PubMed score by year
PubTator Score 762.56
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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GWAS Trait