Tbio CEACAM5 Carcinoembryonic antigen-related cell adhesion molecule 5

Protein Summary

Description

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P06731
• H9KVA7

Gene Name

• CEACAM5

Ensembl ID

• ENST00000221992
• ENSP00000221992
• ENSG00000105388
• ENST00000398599
• ENSP00000381600
• ENST00000405816
• ENSP00000385072

Symbol

• CEA
• CEA
• CD66e

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.86
cell type or tissue	0.85
protein domain	0.85
small molecule perturbation	0.75
cellular component	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14525.26   (req: < 5)

Gene RIFs: 244   (req: <= 3)

Antibodies: 2952   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14525.26   (req: >= 5)

Gene RIFs: 244   (req: > 3)

Antibodies: 2952   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0