Tchem EIF4E Eukaryotic translation initiation factor 4E

Protein Summary

Description

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P06730
• B7Z6V1
• D6RCQ6
• Q96E95
• eIF-4E

Gene Name

• EIF4E

Ensembl ID

• ENST00000280892
• ENSP00000280892
• ENSG00000151247
• ENST00000450253
• ENSP00000389624
• ENST00000505992
• ENSP00000425561

Symbol

• EIF4EL1
• EIF4F
• CBP
• EIF4F
• AUTS19
• EIF4E1
• eIF-4E
• EIF4EL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.97
interacting protein	0.92
microRNA	0.84
transcription factor binding site profile	0.84
biological process	0.77

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4e

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 4e

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.13   (req: < 5)

Gene RIFs: 284   (req: <= 3)

Antibodies: 885   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.13   (req: >= 5)

Gene RIFs: 284   (req: > 3)

Antibodies: 885   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1