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Tchem
EIF4E
Eukaryotic translation initiation factor 4E

Protein Summary
Description
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Altern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280892
  • ENSP00000280892
  • ENSG00000151247
  • ENST00000450253
  • ENSP00000389624
  • ENST00000505992
  • ENSP00000425561

Symbol
  • EIF4EL1
  • EIF4F
  • CBP
  • EIF4F
  • AUTS19
  • EIF4E1
  • eIF-4E
  • EIF4EL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
interacting protein
0.92
microRNA
0.84
transcription factor binding site profile
0.84
biological process
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1454.51   (req: < 5)
Gene RIFs: 240   (req: <= 3)
Antibodies: 885   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1454.51   (req: >= 5)
Gene RIFs: 240   (req: > 3)
Antibodies: 885   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sirolimus
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
48.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
48.6
Protein Data Bank (25)
1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (63)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cap-dependent Translation Initiation
Reactome
Cytokine Signaling in Immune system
Reactome
Deadenylation of mRNA
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Antiviral mechanism by IFN-stimulated genes
Cap-dependent Translation Initiation
Cytokine Signaling in Immune system
Deadenylation of mRNA
Gene Ontology Terms (35)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (458)
1 – 10 of 458
EIF4G3
Tbio
Novelty: 0.03002723
p_int: 0.999999967
p_ni: 3.3e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF4ENIF1
Tbio
Novelty: 0.03835664
p_int: 0.999999896
p_ni: 1.02e-7
p_wrong: 2e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
EIF4EBP2
Tbio
Novelty: 0.01926413
p_int: 0.999999701
p_ni: 4e-9
p_wrong: 2.95e-7
Score: 0.991
Data Source: BioPlex,STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
p_int: 0.999983917
p_ni: 0.000016083
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ANGEL1
Tbio
Novelty: 0.61303879
p_int: 0.99995712
p_ni: 0.000041937
p_wrong: 9.43e-7
Score: 0.677
Data Source: BioPlex,STRINGDB
EIF4EBP1
Tbio
Novelty: 0.00098313
p_int: 0.99991077
p_ni: 0.000089231
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF4EBP3
Tbio
Novelty: 0.12272754
p_int: 0.99984316
p_ni: 0.00015684
Score: 0.99
Data Source: BioPlex,STRINGDB
EIF4A1
Tchem
Novelty: 0.00269994
p_int: 0.994918898
p_ni: 0.005081102
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF4A2
Tbio
Novelty: 0.00298045
Score: 0.999
Data Source: Reactome,STRINGDB
EIF4B
Tbio
Novelty: 0.00665561
Score: 0.996
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1454.51

PubMed score by year
PubTator Score  1008.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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