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Tclin
CD2
T-cell surface antigen CD2

Protein Summary
Description
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369478
  • ENSP00000358490
  • ENSG00000116824

Symbol
  • SRBC
  • T11
  • SRBC
  • LFA-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
biological process
0.77
protein domain
0.73
tissue sample
0.72
cellular component
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2445.14   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 2418   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2445.14   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 2418   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
alefacept
no chemical structure image available
Active Ligands (1)
1 – 1 of 1
CHEMBL2153728
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
6.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD2 molecule
VGNC:5009
449512
Mouse
MGI:88320
12481
Rat
RGD:2297
497761
Dog
CD2 molecule
VGNC:38937
607448
Horse
CD2 molecule
VGNC:16249
100034205
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD2 molecule
Mouse
Rat
Dog
CD2 molecule
Horse
CD2 molecule
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06729-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (233)
1 – 10 of 233
CD58
Tbio
Novelty: 0.0021531
Score: 0.999
Data Source: Reactome,STRINGDB
CD247
Tbio
Novelty: 0.00217194
Score: 0.991
Data Source: STRINGDB
CD28
Tbio
Novelty: 0.00036482
Score: 0.98
Data Source: STRINGDB
CD5
Tbio
Novelty: 0.00032883
Score: 0.978
Data Source: STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.965
Data Source: STRINGDB
FCGR3A
Tbio
Novelty: 0.0004214
Score: 0.953
Data Source: STRINGDB
CD7
Tbio
Novelty: 0.00107937
Score: 0.95
Data Source: STRINGDB
FCGR3B
Tbio
Novelty: 0.000429
Score: 0.946
Data Source: STRINGDB
CD48
Tbio
Novelty: 0.00301661
Score: 0.942
Data Source: STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  2445.14

PubMed score by year
PubTator Score  2603.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer