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Tbio
APOA4
Apolipoprotein A-IV

Protein Summary
Description
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357780
  • ENSP00000350425
  • ENSG00000110244
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
biological term
0.76
disease
0.67
gene perturbation
0.66
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.92   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.92   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (200)
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999340084
p_ni:  4.1e-8
p_wrong:  0.000659875
Score:  0.314
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.997653693
p_ni:  4.87e-7
p_wrong:  0.002345821
Score:  0.196
Data Source:  BioPlex,STRINGDB
APOC3
Tclin
Novelty:  0.0009635
Score:  0.99
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.988
Data Source:  STRINGDB
CREB3L3
Tbio
Family:  TF
Novelty:  0.02519904
Score:  0.981
Data Source:  STRINGDB
APOC2
Tbio
Novelty:  0.0015496
Score:  0.975
Data Source:  STRINGDB
APOA2
Tbio
Novelty:  0.00117627
Score:  0.964
Data Source:  STRINGDB
MTTP
Tclin
Novelty:  0.00212548
Score:  0.96
Data Source:  STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.956
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Chylomicron assembly
Reactome
Chylomicron remodeling
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Assembly of active LPL and LIPC lipase complexes
Chylomicron assembly
Chylomicron remodeling
G alpha (i) signalling events
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (57)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (117)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
50
56
146
11
100
high density lipoprotein cholesterol measurement
28
33
79
1.8
99.9
low density lipoprotein cholesterol measurement
15
14
21
99.9
apolipoprotein A 1 measurement
2
12
13
99.8
total cholesterol measurement
14
22
38
3.5
99.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
146
11
100
high density lipoprotein cholesterol measurement
79
1.8
99.9
low density lipoprotein cholesterol measurement
21
99.9
apolipoprotein A 1 measurement
13
99.8
total cholesterol measurement
38
3.5
99.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A4
VGNC:10229
466792
Macaque
apolipoprotein A4 [Source:HGNC Symbol;Acc:HGNC:602]
Mouse
MGI:88051
11808
Rat
RGD:2132
25080
Dog
apolipoprotein A4
VGNC:53263
489392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A4
Macaque
apolipoprotein A4 [Source:HGNC Symbol;Acc:HGNC:602]
Mouse
Rat
Dog
apolipoprotein A4
Publication Statistics
PubMed Score 258.92
PubMed score by year
PubTator Score 414.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title