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Tbio
APOA4
Apolipoprotein A-IV

Protein Summary
Description
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357780
  • ENSP00000350425
  • ENSG00000110244
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
biological term
0.76
disease
0.67
gene perturbation
0.66
cell type or tissue
0.61


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.87   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.87   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
1
7.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
7.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A4
VGNC:10229
466792
Macaque
apolipoprotein A4 [Source:HGNC Symbol;Acc:HGNC:602]
Mouse
MGI:88051
11808
Rat
RGD:2132
25080
Dog
apolipoprotein A4
VGNC:53263
489392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A4
Macaque
apolipoprotein A4 [Source:HGNC Symbol;Acc:HGNC:602]
Mouse
Rat
Dog
apolipoprotein A4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (28)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Chylomicron assembly
Reactome
Chylomicron remodeling
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Assembly of active LPL and LIPC lipase complexes
Chylomicron assembly
Chylomicron remodeling
G alpha (i) signalling events
Gene Ontology Terms (57)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (200)
1 – 10 of 200
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999340084
p_ni: 4.1e-8
p_wrong: 0.000659875
Score: 0.314
Data Source: BioPlex,STRINGDB
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.997653693
p_ni: 4.87e-7
p_wrong: 0.002345821
Score: 0.196
Data Source: BioPlex,STRINGDB
APOC3
Tclin
Novelty: 0.0009635
Score: 0.99
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.988
Data Source: STRINGDB
CREB3L3
Tbio
Family: TF
Novelty: 0.02519904
Score: 0.981
Data Source: STRINGDB
APOC2
Tbio
Novelty: 0.0015496
Score: 0.975
Data Source: STRINGDB
APOA2
Tbio
Novelty: 0.00117627
Score: 0.964
Data Source: STRINGDB
MTTP
Tclin
Novelty: 0.00212548
Score: 0.96
Data Source: STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.956
Data Source: STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  251.87

PubMed score by year
PubTator Score  414.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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