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Tbio
S100A6
Protein S100-A6

Protein Summary
Description
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368719
  • ENSP00000357708
  • ENSG00000197956
  • ENST00000368720
  • ENSP00000357709
  • ENST00000496817
  • ENSP00000473589

Symbol
  • CACY
  • 2A9
  • PRA
  • 5B10
  • CABP
  • CACY
  • S10A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.97
disease perturbation
0.96
kinase perturbation
0.95
gene perturbation
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.56   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 465   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.56   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
24.4
high density lipoprotein cholesterol measurement
1
1
1
6.9
sleep duration
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
24.4
high density lipoprotein cholesterol measurement
1
6.9
sleep duration
1
6.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A6
VGNC:1529
738116
Macaque
S100 calcium binding protein A6
715169
Mouse
MGI:1339467
20200
Rat
RGD:620264
85247
Dog
S100 calcium binding protein A6
VGNC:45832
480143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S100 calcium binding protein A6
Macaque
S100 calcium binding protein A6
Mouse
Rat
Dog
S100 calcium binding protein A6
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06703-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Prostaglandin Synthesis and Regulation
WikiPathways
Gastric Cancer Network 2
WikiPathways
Vitamin D Receptor Pathway
Name
Explore in Pharos
Explore in Source
Prostaglandin Synthesis and Regulation
Gastric Cancer Network 2
Vitamin D Receptor Pathway
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (77)
1 – 10 of 77
CHCHD7
Tdark
Novelty:  0.03220354
p_int:  0.988384885
p_ni:  0.011615114
p_wrong:  1e-9
Score:  0.685
Data Source:  BioPlex,STRINGDB
MANBAL
Tdark
Novelty:  0.83071311
p_int:  0.987494979
p_ni:  0.01250502
p_wrong:  1e-9
Score:  0.54
Data Source:  BioPlex,STRINGDB
TBC1D2B
Tdark
Novelty:  0.52348266
p_int:  0.97637018
p_ni:  0.023628781
p_wrong:  0.000001039
Score:  0.219
Data Source:  BioPlex,STRINGDB
UFM1
Tbio
Novelty:  0.0215914
p_int:  0.951969669
p_ni:  0.048030307
p_wrong:  2.4e-8
Score:  0.54
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.810266449
p_ni:  0.006341478
p_wrong:  0.183392073
Data Source:  BioPlex
CACYBP
Tbio
Novelty:  0.02207811
Score:  0.975
Data Source:  STRINGDB
AGER
Tchem
Novelty:  0.00061101
Score:  0.926
Data Source:  STRINGDB
ANXA11
Tbio
Novelty:  0.00925429
Score:  0.837
Data Source:  STRINGDB
RB1
Tchem
Novelty:  0.00063798
Score:  0.831
Data Source:  STRINGDB
S100A10
Tbio
Novelty:  0.00281525
Score:  0.812
Data Source:  STRINGDB
Publication Statistics
PubMed Score  587.56

PubMed score by year
PubTator Score  396.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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