Protein Summary
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular ...more
- ENST00000368738
- ENSP00000357727
- ENSG00000163220
- CAGB
- CFAG
- MRP14
- MIF
- NIF
- P14
- CAGB
- CFAG
- CGLB
- L1AG
- LIAG
- MRP14
- 60B8AG
- MAC387
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.99 | ||
biological process | 0.97 | ||
protein complex | 0.97 | ||
small molecule perturbation | 0.97 | ||
molecular function | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 539.46 (req: < 5)
Gene RIFs: 363 (req: <= 3)
Antibodies: 1077 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 539.46 (req: >= 5)
Gene RIFs: 363 (req: > 3)
Antibodies: 1077 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (17)
Protein-Protein Interactions (146)
GNPAT
Family: Enzyme
Novelty: 0.01255689
p_int: 0.99950791
p_ni: 0.00049209
Data Source: BioPlex
PCYOX1
Family: Enzyme
Novelty: 0.18505748
p_int: 0.937383014
p_ni: 0.062616986
Data Source: BioPlex
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.929092774
p_ni: 0.070907226
Data Source: BioPlex
SUSD3
Novelty: 0.43699506
p_int: 0.897039958
p_ni: 0.102960042
Score: 0.208
Data Source: BioPlex,STRINGDB
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.870608509
p_ni: 0.129391491
Data Source: BioPlex
Nearest Tclin Targets
Pathways (15)
Reactome (11)
KEGG (1)
PathwayCommons (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metal sequestration by antimicrobial proteins | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antimicrobial peptides | ||||
Immune System | ||||
Innate Immune System | ||||
Metal sequestration by antimicrobial proteins | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (45)
Functions (7)
Components (12)
Processes (26)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil percentage of leukocytes | 1 | 1 | 1 | 38.2 | |||||
monocyte percentage of leukocytes | 2 | 1 | 2 | 34.8 | |||||
monocyte count | 1 | 1 | 1 | 28 | |||||
basophil percentage of leukocytes | 1 | 1 | 1 | 17 | |||||
matrix metalloproteinase 8 measurement | 1 | 1 | 1 | 14.2 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil percentage of leukocytes | 1 | 38.2 | |||||
monocyte percentage of leukocytes | 2 | 34.8 | |||||
monocyte count | 1 | 28 | |||||
basophil percentage of leukocytes | 1 | 17 | |||||
matrix metalloproteinase 8 measurement | 1 | 14.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein A9 | VGNC:1646 | 457998 | |||||
Macaque | S100 calcium binding protein A9 | 714690 | ||||||
Mouse | MGI:1338947 | 20202 | ||||||
Rat | RGD:620267 | 94195 | ||||||
Horse | S100 calcium binding protein A9 | 100061730 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | S100 calcium binding protein A9 | |||||
Macaque | S100 calcium binding protein A9 | |||||
Mouse | ||||||
Rat | ||||||
Horse | S100 calcium binding protein A9 | |||||
Publication Statistics
PubMed Score 539.46
PubMed score by year
PubTator Score 660.32
PubTator score by year
Related Publications
Text Mined References (414)
GeneRif Annotations (363)
Items per page:
0 of 0
PMID | Year | Title |
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