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Tchem
C2
Complement C2

Protein Summary
Description
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299367
  • ENSP00000299367
  • ENSG00000166278
  • ENST00000375510
  • ENSP00000364660
  • ENSG00000204364
  • ENST00000383362
  • ENSP00000372853
  • ENSG00000206372
  • ENST00000411803
  • ENSP00000402278
  • ENSG00000235696
  • ENST00000413548
  • ENSP00000407961
  • ENSG00000231543
  • ENST00000416252
  • ENSP00000405800
  • ENSG00000235017
  • ENST00000442278
  • ENSP00000395683
  • ENST00000448206
  • ENSP00000392835
  • ENSG00000226560
  • ENST00000452323
  • ENSP00000392322
  • ENST00000548973
  • ENSP00000446728
  • ENST00000548995
  • ENSP00000449286
  • ENST00000549972
  • ENSP00000447632
  • ENST00000550682
  • ENSP00000446639
  • ENST00000551081
  • ENSP00000450387
  • ENST00000551648
  • ENSP00000449715
  • ENST00000612228
  • ENSP00000482616
  • ENST00000615380
  • ENSP00000481651
  • ENST00000618254
  • ENSP00000483231
  • ENST00000621558
  • ENSP00000480739

Symbol
  • CO2
  • ARMD14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
protein domain
0.92
virus perturbation
0.9
disease
0.79
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.15   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.15   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0