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Tchem
C2
Complement C2

Protein Summary
Description
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299367
  • ENSP00000299367
  • ENSG00000166278
  • ENST00000375510
  • ENSP00000364660
  • ENSG00000204364
  • ENST00000383362
  • ENSP00000372853
  • ENSG00000206372
  • ENST00000411803
  • ENSP00000402278
  • ENSG00000235696
  • ENST00000413548
  • ENSP00000407961
  • ENSG00000231543
  • ENST00000416252
  • ENSP00000405800
  • ENSG00000235017
  • ENST00000442278
  • ENSP00000395683
  • ENST00000448206
  • ENSP00000392835
  • ENSG00000226560
  • ENST00000452323
  • ENSP00000392322
  • ENST00000548973
  • ENSP00000446728
  • ENST00000548995
  • ENSP00000449286
  • ENST00000549972
  • ENSP00000447632
  • ENST00000550682
  • ENSP00000446639
  • ENST00000551081
  • ENSP00000450387
  • ENST00000551648
  • ENSP00000449715
  • ENST00000612228
  • ENSP00000482616
  • ENST00000615380
  • ENSP00000481651
  • ENST00000618254
  • ENSP00000483231
  • ENST00000621558
  • ENSP00000480739

Symbol
  • CO2
  • ARMD14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
protein domain
0.92
virus perturbation
0.9
disease
0.79
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.32   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.32   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL4247125
Rendered image for CHEMBL4247125
GWAS Traits (158)
Items per page:
1 – 5 of 158
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
9
0
1.9
99.3
9
9
0
1.9
99.3
6
6
0
2.3
99.2
6
6
0
2.3
99.2
3
5
0
1.8
98.7
Items per page:
1 – 5 of 158
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
99.3
0
1.9
99.3
0
2.3
99.2
0
2.3
99.2
0
1.8
98.7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C2
VGNC:11038
100608992
Mouse
MGI:88226
12263
Horse
complement C2
VGNC:15947
100059162
Cow
complement C2
VGNC:53959
515440
Pig
complement C2
448981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C2
Mouse
Horse
complement C2
Cow
complement C2
Pig
complement C2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06681-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Activation of C3 and C5 (R-HSA-174577)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of C3 and C5
Reactome
Complement cascade
Reactome
Immune System
Reactome
Initial triggering of complement
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Activation of C3 and C5
Complement cascade
Immune System
Initial triggering of complement
Innate Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (77)
1 – 10 of 77
CD55
Tbio
Novelty:  0.0005689
p_int:  0.999941524
p_ni:  0.000029745
p_wrong:  0.000028731
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.984
Data Source:  Reactome,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
C4B
Tbio
Novelty:  0.00068357
Score:  0.976
Data Source:  Reactome,STRINGDB
C4A
Tbio
Novelty:  0.00062793
Score:  0.963
Data Source:  Reactome,STRINGDB
C5
Tclin
Novelty:  0.00225386
Score:  0.963
Data Source:  Reactome,STRINGDB
CFI
Tbio
Novelty:  0.00271423
Score:  0.959
Data Source:  STRINGDB
MBL2
Tbio
Novelty:  0.00124156
Score:  0.955
Data Source:  Reactome,STRINGDB
C1R
Tclin
Novelty:  0.00210654
Score:  0.948
Data Source:  Reactome,STRINGDB
FCN2
Tbio
Novelty:  0.00519137
Score:  0.946
Data Source:  STRINGDB
Publication Statistics
PubMed Score  80.32

PubMed score by year
PubTator Score  41434.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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