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Tbio
ATP5F1B
ATP synthase subunit beta, mitochondrial

Protein Classes
Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262030
  • ENSP00000262030
  • ENSG00000110955

Symbol
  • ATP5B
  • ATPMB
  • ATPSB
  • ATP5B
  • ATPMB
  • ATPSB
  • HEL-S-271
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.09   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.09   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
45.3
mean platelet volume
1
1
1
18.1
reticulocyte count
1
1
1
10.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
45.3
mean platelet volume
1
18.1
reticulocyte count
1
10.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase F1 subunit beta
VGNC:12792
451999
Mouse
MGI:107801
11947
Rat
RGD:621368
171374
Dog
ATP synthase F1 subunit beta
403669
Horse
ATP synthase F1 subunit beta
VGNC:15660
100059825
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase F1 subunit beta
Mouse
Rat
Dog
ATP synthase F1 subunit beta
Horse
ATP synthase F1 subunit beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P06576-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial protein import
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Mitochondrial protein import
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred by Curator (IC)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (418)
1 – 10 of 418
ATPAF1
Tbio
Family: Enzyme
Novelty: 0.04032579
p_int: 0.999994358
p_ni: 0.000005642
Score: 0.973
Data Source: BioPlex,STRINGDB
ATP5PB
Tbio
Family: Enzyme
Novelty: 0.07345384
p_int: 0.999993774
p_ni: 0.000006226
Score: 0.999
Data Source: BioPlex,STRINGDB
DNAJC28
Tbio
Novelty: 0.02849281
p_int: 0.999877535
p_ni: 0.000122465
Score: 0.525
Data Source: BioPlex,STRINGDB
ATP5F1C
Tbio
Family: Enzyme
Novelty: 0.07666564
p_int: 0.999458041
p_ni: 0.000541959
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP5F1D
Tbio
Family: Enzyme
Novelty: 0.07296539
p_int: 0.999433331
p_ni: 0.000566669
Score: 0.999
Data Source: BioPlex,STRINGDB
ZFYVE27
Tbio
Novelty: 0.0563358
p_int: 0.998426342
p_ni: 0.001573658
Score: 0.537
Data Source: BioPlex,STRINGDB
ATP5PD
Tbio
Family: Enzyme
Novelty: 0.0730514
p_int: 0.99816696
p_ni: 0.001833037
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP5MC3
Tdark
Family: Enzyme
Novelty: 0.04850603
p_int: 0.997277101
p_ni: 0.002722899
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.01052213
p_int: 0.996480504
p_ni: 0.003519496
Score: 0.999
Data Source: BioPlex,STRINGDB
MT-ATP8
Tbio
Family: Enzyme
Novelty: 0.00249065
p_int: 0.99532007
p_ni: 0.004663709
p_wrong: 0.000016221
Score: 0.977
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  82.09

PubMed score by year
PubTator Score  34.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer