Tbio ATP5F1B ATP synthase subunit beta, mitochondrial

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Atp Synthase Subunit Beta, Mitochondrial

Protein / Transporter / Ion Channel / Anion Channel / Atp Synthase Subunit Beta, Mitochondrial

Protein / Transporter / Cation Transporter / Atp Synthase / Atp Synthase Subunit Beta, Mitochondrial

Protein / Receptor / Ligand-gated Ion Channel / Atp Synthase Subunit Beta, Mitochondrial

Protein / Nucleic Acid Binding / Dna Binding Protein / Atp Synthase Subunit Beta, Mitochondrial

Protein / Hydrolase / Protease / Atp Synthase Subunit Beta, Mitochondrial

DTO Classes

Protein / Transporter / F-type And V-type Atpases / F-type Atpase / Atp Synthase Subunit Beta, Mitochondrial

Protein Summary

Description

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P06576
• A8K4X0
• Q14283

Gene Name

• ATP5F1B

Ensembl ID

• ENST00000262030
• ENSP00000262030
• ENSG00000110955

Symbol

• ATP5B
• ATPMB
• ATPSB
• ATP5B
• ATPMB
• ATPSB
• HEL-S-271

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.09   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 470   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.09   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2	2	2		45.3
mean platelet volume	EFO_0004584	1	1	1		18.1
reticulocyte count	EFO_0007986	1	1	1		10.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2		45.3
mean platelet volume	EFO_0004584	1		18.1
reticulocyte count	EFO_0007986	1		10.6

Reset Zoom  Beta Count   Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ATP synthase F1 subunit beta	VGNC:12792	451999
Mouse	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	MGI:107801	11947
Rat	ATP synthase F1 subunit beta	RGD:621368	171374
Dog	ATP synthase F1 subunit beta		403669
Horse	ATP synthase F1 subunit beta	VGNC:15660	100059825

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ATP synthase F1 subunit beta
Mouse	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
Rat	ATP synthase F1 subunit beta
Dog	ATP synthase F1 subunit beta
Horse	ATP synthase F1 subunit beta

Pathways (19)

Reactome (10)

KEGG (6)

PathwayCommons (1)

WikiPathways (2)

Cristae formation (R-HSA-8949613)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cristae formation	28 targets	R-HSA-8949613
Reactome	Formation of ATP by chemiosmotic coupling	17 targets	R-HSA-163210
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Mitochondrial biogenesis	89 targets	R-HSA-1592230
Reactome	Mitochondrial protein import	65 targets	R-HSA-1268020

Name	Explore in Pharos	Explore in Source
Cristae formation	28 targets	R-HSA-8949613
Formation of ATP by chemiosmotic coupling	17 targets	R-HSA-163210
Metabolism	2112 targets	R-HSA-1430728
Mitochondrial biogenesis	89 targets	R-HSA-1592230
Mitochondrial protein import	65 targets	R-HSA-1268020

Gene Ontology Terms (32)

Functions (7)

Components (13)

Processes (12)

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1 – 7 of 7

GO Term	Evidence	Assigned by
MHC class I protein binding	Inferred from Direct Assay (IDA)	UniProtKB
angiostatin binding	Inferred from Physical Interaction (IPI)	CAFA
proton-transporting ATP synthase activity, rotational mechanism	Inferred from Mutant Phenotype (IMP)	CAFA
proton-transporting ATPase activity, rotational mechanism	Inferred from Mutant Phenotype (IMP)	UniProtKB
transporter activity	Non-traceable Author Statement (NAS)	UniProtKB
transmembrane transporter activity	Inferred by Curator (IC)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (418)

Explore Interacting Targets

1 – 10 of 418

• See Interactions on String-DB

ATPAF1

Tbio

Family: Enzyme

Novelty: 0.04032579

p_int: 0.999994358

p_ni: 0.000005642

Score: 0.973

Data Source: BioPlex,STRINGDB

ATP5PB

Tbio

Family: Enzyme

Novelty: 0.07345384

p_int: 0.999993774

p_ni: 0.000006226

Score: 0.999

Data Source: BioPlex,STRINGDB

DNAJC28

Tbio

Novelty: 0.02849281

p_int: 0.999877535

p_ni: 0.000122465

Score: 0.525

Data Source: BioPlex,STRINGDB

ATP5F1C

Tbio

Family: Enzyme

Novelty: 0.07666564

p_int: 0.999458041

p_ni: 0.000541959

Score: 0.999

Data Source: BioPlex,STRINGDB

ATP5F1D

Tbio

Family: Enzyme

Novelty: 0.07296539

p_int: 0.999433331

p_ni: 0.000566669

Score: 0.999

Data Source: BioPlex,STRINGDB

ZFYVE27

Tbio

Novelty: 0.0563358

p_int: 0.998426342

p_ni: 0.001573658

Score: 0.537

Data Source: BioPlex,STRINGDB

ATP5PD

Tbio

Family: Enzyme

Novelty: 0.0730514

p_int: 0.99816696

p_ni: 0.001833037

p_wrong: 3e-9

Score: 0.999

Data Source: BioPlex,STRINGDB

ATP5MC3

Tdark

Family: Enzyme

Novelty: 0.04850603

p_int: 0.997277101

p_ni: 0.002722899

Score: 0.999

Data Source: BioPlex,STRINGDB

ATP5F1A

Tbio

Family: Enzyme

Novelty: 0.01052213

p_int: 0.996480504

p_ni: 0.003519496

Score: 0.999

Data Source: BioPlex,STRINGDB

MT-ATP8

Tbio

Family: Enzyme

Novelty: 0.00249065

p_int: 0.99532007

p_ni: 0.004663709

p_wrong: 0.000016221

Score: 0.977

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  82.09

PubMed score by year

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PubTator Score  34.83

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
ATP synthesis
ATP-binding
CF(1)
Complete proteome
Direct protein sequencing
Glycoprotein
Hydrogen ion transport
Ion transport
Membrane

GWAS Trait Find Similar Targets

mean platelet volume
reticulocyte count
reticulocyte measurement

MGI Phenotype Find Similar Targets

mortality/aging