Protein Summary
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000373808
- ENSP00000362914
- ENSG00000148180
- ENST00000373818
- ENSP00000362924
- ENST00000373823
- ENSP00000362929
- ENST00000545652
- ENSP00000445823
- ADF
- AGEL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 1 | ||
biological process | 0.99 | ||
hub protein | 0.98 | ||
PubMedID | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1893.12 (req: < 5)
Gene RIFs: 178 (req: <= 3)
Antibodies: 643 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1893.12 (req: >= 5)
Gene RIFs: 178 (req: > 3)
Antibodies: 643 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0