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Tbio
HLA-DOA
HLA class II histocompatibility antigen, DO alpha chain

Protein Summary
Description
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229829
  • ENSP00000229829
  • ENSG00000204252
  • ENST00000383226
  • ENSP00000372713
  • ENSG00000206292
  • ENST00000426070
  • ENSP00000401504
  • ENSG00000231558
  • ENST00000426685
  • ENSP00000397945
  • ENSG00000232957
  • ENST00000434335
  • ENSP00000416448
  • ENSG00000232962
  • ENST00000438987
  • ENSP00000395737
  • ENSG00000230141
  • ENST00000452598
  • ENSP00000398819
  • ENSG00000235744

Symbol
  • HLA-DNA
  • HLA-DZA
  • HLADZ
  • HLA-DNA
  • HLA-DZA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
disease perturbation
0.79
cell type or tissue
0.73
cellular component
0.73
tissue sample
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.97   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.97   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronic hepatitis B virus infection
1
1
0
1.3
84.7
chronic hepatitis B virus infection
1
1
0
1.3
84.7
chronic hepatitis B virus infection
1
1
0
1.3
84.7
chronic hepatitis B virus infection
1
1
0
1.3
84.7
chronic hepatitis B virus infection
1
1
0
1.3
84.7
Items per page:
1 – 5 of 23
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronic hepatitis B virus infection
0
1.3
84.7
chronic hepatitis B virus infection
0
1.3
84.7
chronic hepatitis B virus infection
0
1.3
84.7
chronic hepatitis B virus infection
0
1.3
84.7
chronic hepatitis B virus infection
0
1.3
84.7
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
major histocompatibility complex, class II, DO alpha
717947
Mouse
MGI:95924
15001
Rat
RGD:3477
24984
Dog
HLA class II histocompatibility antigen, DO alpha chain-like
474869
Species
Name
OMA
EggNOG
Inparanoid
Macaque
major histocompatibility complex, class II, DO alpha
Mouse
Rat
Dog
HLA class II histocompatibility antigen, DO alpha chain-like
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
MHC class II antigen presentation
Protein-Protein Interactions (169)
1 – 10 of 169
HTR3A
Tclin
Family: IC
Novelty: 0.00217443
p_int: 0.999998446
p_ni: 0.000001394
p_wrong: 1.6e-7
Score: 0.186
Data Source: BioPlex,STRINGDB
ITM2A
Tbio
Novelty: 0.06374858
p_int: 0.999770021
p_ni: 0.000011449
p_wrong: 0.00021853
Score: 0.297
Data Source: BioPlex,STRINGDB
HLA-DMA
Tbio
Novelty: 0.00405566
Score: 0.99
Data Source: Reactome,STRINGDB
HLA-DOB
Tbio
Novelty: 0.04212117
Score: 0.99
Data Source: Reactome,STRINGDB
HLA-DMB
Tbio
Novelty: 0.02289537
Score: 0.966
Data Source: Reactome,STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.956
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.956
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.956
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.956
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  80.97

PubMed score by year
PubTator Score  70.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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