Tbio HLA-DOA HLA class II histocompatibility antigen, DO alpha chain

Protein Summary

Description

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P06340
• Q58HU0
• Q58HU1
• Q5STC7
• Q9TQC6
• Q9TQC7
• Q9TQC8
• Q9TQC9
• Q9TQD0
• Q9TQD1
• Q9TQD2
• Q9TQD3

Gene Name

• HLA-DOA

Ensembl ID

• ENST00000229829
• ENSP00000229829
• ENSG00000204252
• ENST00000383226
• ENSP00000372713
• ENSG00000206292
• ENST00000426070
• ENSP00000401504
• ENSG00000231558
• ENST00000426685
• ENSP00000397945
• ENSG00000232957
• ENST00000434335
• ENSP00000416448
• ENSG00000232962
• ENST00000438987
• ENSP00000395737
• ENSG00000230141
• ENST00000452598
• ENSP00000398819
• ENSG00000235744

Symbol

• HLA-DNA
• HLA-DZA
• HLADZ
• HLA-DNA
• HLA-DZA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
disease perturbation	0.79
cell type or tissue	0.73
cellular component	0.73
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Defense/immunity Protein / Major Histocompatibility Complex Antigen / Hla Class Ii Histocompatibility Antigen, Do Alpha Chain

DTO Classes

Protein / Immune Response / Major Histocompatibility Complex Antigen / Hla Class Ii Histocompatibility Antigen, Do Alpha Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.71   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.71   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0