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Tbio
CCK
Cholecystokinin

Protein Summary
Description
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334681
  • ENSP00000335657
  • ENSG00000187094
  • ENST00000396169
  • ENSP00000379472
  • ENST00000434608
  • ENSP00000409124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
biological process
0.89
biological term
0.76
chemical
0.62
disease
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8965.43   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8965.43   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
5
7
86.7
comparative body size at age 10, self-reported
1
1
1
56.6
physical activity measurement
1
2
2
28.1
body height
1
1
1
11.7
visceral adipose tissue measurement
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
86.7
comparative body size at age 10, self-reported
1
56.6
physical activity measurement
2
28.1
body height
1
11.7
visceral adipose tissue measurement
1
4.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholecystokinin
VGNC:1762
460290
Macaque
cholecystokinin
100430777
Mouse
MGI:88297
12424
Rat
RGD:2288
25298
Dog
cholecystokinin
VGNC:52865
609547
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholecystokinin
Macaque
cholecystokinin
Mouse
Rat
Dog
cholecystokinin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P06307-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (32)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (355)
1 – 10 of 355
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.999948611
p_ni:  0.000051374
p_wrong:  1.5e-8
Data Source:  BioPlex
CCKBR
Tclin
Family:  GPCR
Novelty:  0.00158159
Score:  0.998
Data Source:  Reactome,STRINGDB
CCKAR
Tclin
Family:  GPCR
Novelty:  0.00152339
Score:  0.997
Data Source:  Reactome,STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.992
Data Source:  STRINGDB
GRP
Tbio
Novelty:  0.00034247
Score:  0.989
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.986
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.986
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.985
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.985
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.983
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8965.43

PubMed score by year
PubTator Score  2299.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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