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Tclin
BCHE
Cholinesterase

Protein Summary
Description
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264381
  • ENSP00000264381
  • ENSG00000114200

Symbol
  • CHE1
  • E1
  • CHE1
  • CHE2
  • BCHED
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
protein domain
0.85
disease
0.83
molecular function
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4140.56   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4140.56   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1268
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1268)
9,10-phenanthrenequinone
Rendered image for 9,10-phenanthrenequinone
methoctramine
Rendered image for methoctramine
CHEMBL4789145
Rendered image for CHEMBL4789145
Paraoxon
Rendered image for Paraoxon
CHEMBL4470448
Rendered image for CHEMBL4470448
CHEMBL3586577
Rendered image for CHEMBL3586577
CHEMBL3586582
Rendered image for CHEMBL3586582
Protein-Protein Interactions (160)
LOXL1
Tbio
Family:  Enzyme
Novelty:  0.00479897
p_int:  0.999998972
p_ni:  9.95e-7
p_wrong:  3.3e-8
Score:  0.243
Data Source:  BioPlex,STRINGDB
ENTPD5
Tbio
Family:  Enzyme
Novelty:  0.01714402
p_int:  0.999998319
p_ni:  0.000001678
p_wrong:  3e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
LTBP1
Tbio
Novelty:  0.00958396
p_int:  0.999995274
p_ni:  0.000004726
Score:  0.172
Data Source:  BioPlex,STRINGDB
NAF1
Tbio
Novelty:  2.99493689
p_int:  0.999994728
p_ni:  0.000005232
p_wrong:  4e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
ACTN3
Tbio
Novelty:  0.00375035
p_int:  0.999969882
p_ni:  0.000030112
p_wrong:  6e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
PALLD
Tbio
Novelty:  0.01191944
p_int:  0.999907709
p_ni:  0.00009084
p_wrong:  0.000001451
Score:  0.215
Data Source:  BioPlex,STRINGDB
SHTN1
Tbio
Novelty:  0.06452923
p_int:  0.99976861
p_ni:  0.000231385
p_wrong:  4e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
SMR3B
Tdark
Novelty:  0.0284503
p_int:  0.999761495
p_ni:  0.000238505
Score:  0.158
Data Source:  BioPlex,STRINGDB
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
p_int:  0.999452332
p_ni:  0.000547637
p_wrong:  3.1e-8
Score:  0.86
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.999121695
p_ni:  0.000878305
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Metabolism of proteins
Neuronal System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
2
1
2
96.3
blood protein measurement
25
9
27
95.6
high density lipoprotein cholesterol measurement
1
1
1
94.1
triglyceride measurement
1
1
1
94.1
uric acid measurement
1
1
1
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
2
96.3
blood protein measurement
27
95.6
high density lipoprotein cholesterol measurement
1
94.1
triglyceride measurement
1
94.1
uric acid measurement
1
94.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
butyrylcholinesterase
VGNC:1746
460830
Macaque
butyrylcholinesterase
700484
Mouse
MGI:894278
12038
Rat
RGD:619996
65036
Dog
butyrylcholinesterase
VGNC:38405
488143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
butyrylcholinesterase
Macaque
butyrylcholinesterase
Mouse
Rat
Dog
butyrylcholinesterase
Publication Statistics
PubMed Score 4140.56
PubMed score by year
PubTator Score 9377.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title