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Tclin
BCHE
Cholinesterase

Protein Classes
Protein Summary
Description
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. This gene encodes a cholinesterase enzyme and member of the type-B carboxylesterase/lipase family of proteins. The encoded enzyme exhibits broad substrate specificity and is involved in the detoxification of poisons including organophosphate nerve agents and pesticides, and the metabolism of drugs including cocaine, heroin and aspirin. Humans homozygous for certain mutations in this gene exhibit prolonged apnea after administration of the muscle relaxant succinylcholine. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264381
  • ENSP00000264381
  • ENSG00000114200

Symbol
  • CHE1
  • E1
  • CHE1
  • CHE2
  • BCHED
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
protein domain
0.85
disease
0.83
molecular function
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3352.85   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3352.85   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 847
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
Active Ligands (847)
1 – 10 of 847
CHEMBL481153
chemical structure image
CHEMBL51931
chemical structure image
CHEMBL519609
chemical structure image
CHEMBL192627
chemical structure image
CHEMBL3586582
chemical structure image
CHEMBL3586577
chemical structure image
CHEMBL3885186
chemical structure image
CHEMBL1819176
chemical structure image
CHEMBL3304357,CHEMBL3233829
chemical structure image
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
2
1
2
95.3
high density lipoprotein cholesterol measurement
1
1
1
89.3
triglyceride measurement
1
1
1
89.3
uric acid measurement
1
1
1
89.3
low density lipoprotein cholesterol measurement
1
1
1
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
2
95.3
high density lipoprotein cholesterol measurement
1
89.3
triglyceride measurement
1
89.3
uric acid measurement
1
89.3
low density lipoprotein cholesterol measurement
1
89.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
butyrylcholinesterase
VGNC:1746
460830
Macaque
butyrylcholinesterase
700484
Mouse
MGI:894278
12038
Rat
RGD:619996
65036
Dog
butyrylcholinesterase
VGNC:38405
488143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
butyrylcholinesterase
Macaque
butyrylcholinesterase
Mouse
Rat
Dog
butyrylcholinesterase
Protein Structure (53 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06276-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 53
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Metabolism of proteins
Neuronal System
Gene Ontology Terms (22)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (160)
1 – 10 of 160
LOXL1
Tbio
Family: Enzyme
Novelty: 0.00479897
p_int: 0.999998972
p_ni: 9.95e-7
p_wrong: 3.3e-8
Score: 0.243
Data Source: BioPlex,STRINGDB
ENTPD5
Tbio
Family: Enzyme
Novelty: 0.01714402
p_int: 0.999998319
p_ni: 0.000001678
p_wrong: 3e-9
Score: 0.193
Data Source: BioPlex,STRINGDB
LTBP1
Tbio
Novelty: 0.00958396
p_int: 0.999995274
p_ni: 0.000004726
Score: 0.172
Data Source: BioPlex,STRINGDB
NAF1
Tbio
Novelty: 2.99493689
p_int: 0.999994728
p_ni: 0.000005232
p_wrong: 4e-8
Score: 0.213
Data Source: BioPlex,STRINGDB
ACTN3
Tbio
Novelty: 0.00375035
p_int: 0.999969882
p_ni: 0.000030112
p_wrong: 6e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
PALLD
Tbio
Novelty: 0.01191944
p_int: 0.999907709
p_ni: 0.00009084
p_wrong: 0.000001451
Score: 0.215
Data Source: BioPlex,STRINGDB
SHTN1
Tbio
Novelty: 0.06452923
p_int: 0.99976861
p_ni: 0.000231385
p_wrong: 4e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
SMR3B
Tdark
Novelty: 0.0284503
p_int: 0.999761495
p_ni: 0.000238505
Score: 0.158
Data Source: BioPlex,STRINGDB
COLQ
Tbio
Family: Enzyme
Novelty: 0.01414634
p_int: 0.999452332
p_ni: 0.000547637
p_wrong: 3.1e-8
Score: 0.86
Data Source: BioPlex,STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.999121695
p_ni: 0.000878305
Data Source: BioPlex
Publication Statistics
PubMed Score  3352.85

PubMed score by year
PubTator Score  9377.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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