Protein Summary
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5) ...more
- ENST00000302850
- ENSP00000303830
- ENSG00000171105
- ENST00000341500
- ENSP00000342838
- HHF5
- CD220
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
hub protein | 1 | ||
molecular function | 1 | ||
protein domain | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 439.19 (req: < 5)
Gene RIFs: 295 (req: <= 3)
Antibodies: 1926 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 439.19 (req: >= 5)
Gene RIFs: 295 (req: > 3)
Antibodies: 1926 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 65
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 89
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 9
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (9)
Active Ligands (89)
Protein-Protein Interactions (319)
UNC5CL
Novelty: 0.11511991
p_int: 0.999877875
p_ni: 0.000122125
Score: 0.188
Data Source: BioPlex,STRINGDB
IGF2
Novelty: 0.00021277
p_int: 0.976580773
p_ni: 0.023419227
Score: 0.953
Data Source: BioPlex,STRINGDB
DHFR2
Family: Enzyme
Novelty: 0.02374466
p_int: 0.957192758
p_ni: 0.042807243
Data Source: BioPlex
PON2
Family: Enzyme
Novelty: 0.00414855
p_int: 0.952283291
p_ni: 0.047716709
Data Source: BioPlex
PTPRK
Family: Enzyme
Novelty: 0.03149943
p_int: 0.94997313
p_ni: 0.05002687
Score: 0.285
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (67)
Reactome (11)
KEGG (20)
PathwayCommons (15)
WikiPathways (21)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | IRS activation | ||||
Reactome | Insulin receptor recycling | ||||
Reactome | Insulin receptor signalling cascade | ||||
Reactome | Intracellular signaling by second messengers | ||||
Reactome | Negative regulation of the PI3K/AKT network | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
IRS activation | ||||
Insulin receptor recycling | ||||
Insulin receptor signalling cascade | ||||
Intracellular signaling by second messengers | ||||
Negative regulation of the PI3K/AKT network | ||||
Viral Interactions (0)
Gene Ontology Terms (79)
Functions (17)
Components (14)
Processes (48)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 3 | 25 | 27 | 94.2 | |||||
urate measurement | 4 | 4 | 6 | 92.4 | |||||
triglyceride measurement | 6 | 6 | 7 | 92.1 | |||||
BMI-adjusted waist-hip ratio | 2 | 9 | 9 | 86.1 | |||||
waist-hip ratio | 3 | 10 | 11 | 85.4 | |||||
Items per page:
1 – 5 of 36
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 27 | 94.2 | |||||
urate measurement | 6 | 92.4 | |||||
triglyceride measurement | 7 | 92.1 | |||||
BMI-adjusted waist-hip ratio | 9 | 86.1 | |||||
waist-hip ratio | 11 | 85.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | insulin receptor | VGNC:11232 | 455649 | |||||
Mouse | MGI:96575 | 16337 | ||||||
Rat | RGD:2917 | 24954 | ||||||
Dog | insulin receptor | VGNC:42043 | 484990 | |||||
Horse | insulin receptor | VGNC:19083 | 100066248 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | insulin receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | insulin receptor | |||||
Horse | insulin receptor | |||||
Publication Statistics
PubMed Score 439.19
PubMed score by year
PubTator Score 2952.35
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (588)
GeneRif Annotations (295)
Items per page:
0 of 0
PMID | Year | Title |
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