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Tclin
INSR
Insulin receptor

Protein Summary
Description
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302850
  • ENSP00000303830
  • ENSG00000171105
  • ENST00000341500
  • ENSP00000342838

Symbol
  • HHF5
  • CD220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
molecular function
1
protein domain
1


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.19   (req: < 5)
Gene RIFs: 295   (req: <= 3)
Antibodies: 1926   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.19   (req: >= 5)
Gene RIFs: 295   (req: > 3)
Antibodies: 1926   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 89
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
25
27
94.2
urate measurement
4
4
6
92.4
triglyceride measurement
6
6
7
92.1
BMI-adjusted waist-hip ratio
2
9
9
86.1
waist-hip ratio
3
10
11
85.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
27
94.2
urate measurement
6
92.4
triglyceride measurement
7
92.1
BMI-adjusted waist-hip ratio
9
86.1
waist-hip ratio
11
85.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin receptor
VGNC:11232
455649
Mouse
MGI:96575
16337
Rat
RGD:2917
24954
Dog
insulin receptor
VGNC:42043
484990
Horse
insulin receptor
VGNC:19083
100066248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin receptor
Mouse
Rat
Dog
insulin receptor
Horse
insulin receptor
Protein Structure (31 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P06213-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 31
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (67)
IRS activation (R-HSA-74713)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRS activation
Reactome
Insulin receptor recycling
Reactome
Insulin receptor signalling cascade
Reactome
Intracellular signaling by second messengers
Reactome
Negative regulation of the PI3K/AKT network
Name
Explore in Pharos
Explore in Source
IRS activation
Insulin receptor recycling
Insulin receptor signalling cascade
Intracellular signaling by second messengers
Negative regulation of the PI3K/AKT network
Gene Ontology Terms (79)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (319)
1 – 10 of 319
UNC5CL
Tbio
Novelty:  0.11511991
p_int:  0.999877875
p_ni:  0.000122125
Score:  0.188
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.993951292
p_ni:  0.006048708
Data Source:  BioPlex
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.992681225
p_ni:  0.007318776
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.992418197
p_ni:  0.007581803
Data Source:  BioPlex
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.99146048
p_ni:  0.008539521
Data Source:  BioPlex
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.976768249
p_ni:  0.023231752
Data Source:  BioPlex
IGF2
Tbio
Novelty:  0.00021277
p_int:  0.976580773
p_ni:  0.023419227
Score:  0.953
Data Source:  BioPlex,STRINGDB
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.957192758
p_ni:  0.042807243
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.952283291
p_ni:  0.047716709
Data Source:  BioPlex
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.94997313
p_ni:  0.05002687
Score:  0.285
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  439.19

PubMed score by year
PubTator Score  2952.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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