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Tbio
UGT2B4
UDP-glucuronosyltransferase 2B4

Protein Summary
Description
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305107
  • ENSP00000305221
  • ENSG00000156096
  • ENST00000512583
  • ENSP00000421290

Symbol
  • UGT2B11
  • HLUG25
  • UDPGTH1
  • UGT2B11
  • UDPGT2B4
  • UDPGTh-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
molecular function
0.63
pathway
0.61
cell line
0.53
cellular component
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.61   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.61   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP glucuronosyltransferase family 2 member B4
VGNC:8669
461285
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP glucuronosyltransferase family 2 member B4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P06133-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glucuronidation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glucuronidation
Metabolism
Phase II - Conjugation of compounds
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (85)
1 – 10 of 85
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.851
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.839
Data Source: STRINGDB
SLC35A2
Tbio
Family: Transporter
Novelty: 0.00072521
Score: 0.812
Data Source: STRINGDB
CYP2C8
Tchem
Novelty: 0.00186373
Score: 0.812
Data Source: STRINGDB
CYP2C9
Tchem
Novelty: 0.00041914
Score: 0.812
Data Source: STRINGDB
CYP2D6
Tclin
Family: Enzyme
Novelty: 0.00021853
Score: 0.809
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.792
Data Source: STRINGDB
CYP1A2
Tchem
Novelty: 0.00034756
Score: 0.791
Data Source: STRINGDB
CYP3A7
Tclin
Family: Enzyme
Novelty: 0.00736888
Score: 0.785
Data Source: STRINGDB
CYP3A5
Tclin
Family: Enzyme
Novelty: 0.00105607
Score: 0.785
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.61

PubMed score by year
PubTator Score  58.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer