UROD
Uroporphyrinogen decarboxylase
Protein Summary
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]
- ENST00000246337
- ENSP00000246337
- ENSG00000126088
- PCT
- UPD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.96 | ||
histone modification site profile | 0.9 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.74 | ||
tissue sample | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.88 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 222 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.88 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 222 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (173)
PPID
Family: Enzyme
Novelty: 0.01068886
p_int: 0.980868418
p_ni: 0.019131581
Score: 0.359
Data Source: BioPlex,STRINGDB
POTEF
Novelty: 0.00191599
p_int: 0.939611779
p_ni: 0.060388221
Score: 0.272
Data Source: BioPlex,STRINGDB
CPNE5
Novelty: 0.09416684
p_int: 0.857628432
p_ni: 0.142371567
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (3)
KEGG (2)
PathwayCommons (4)
UniProt (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Heme biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of porphyrins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Heme biosynthesis | ||||
Metabolism | ||||
Metabolism of porphyrins | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (1)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | uroporphyrinogen decarboxylase | VGNC:1719 | 456541 | |||||
Macaque | uroporphyrinogen decarboxylase | 705166 | ||||||
Mouse | MGI:98916 | 22275 | ||||||
Rat | RGD:3946 | 29421 | ||||||
Dog | uroporphyrinogen decarboxylase | VGNC:48169 | 475378 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | uroporphyrinogen decarboxylase | |||||
Macaque | uroporphyrinogen decarboxylase | |||||
Mouse | ||||||
Rat | ||||||
Dog | uroporphyrinogen decarboxylase | |||||
Publication Statistics
PubMed Score 304.88
PubMed score by year
PubTator Score 336.98
PubTator score by year
Related Publications
Text Mined References (46)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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