Tbio UROD Uroporphyrinogen decarboxylase

Protein Summary

Description

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• P06132
• A8K762
• Q16863
• Q16883
• Q53YB8
• Q53ZP6
• Q6IB28
• Q9BUZ0
• UPD

Gene Name

• UROD

Ensembl ID

• ENST00000246337
• ENSP00000246337
• ENSG00000126088

Symbol

• PCT
• UPD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
histone modification site profile	0.9
transcription factor perturbation	0.88
transcription factor binding site profile	0.74
tissue sample	0.7

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.58   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.58   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	uroporphyrinogen decarboxylase	VGNC:1719	456541
Macaque	uroporphyrinogen decarboxylase		705166
Mouse	uroporphyrinogen decarboxylase	MGI:98916	22275
Rat	uroporphyrinogen decarboxylase	RGD:3946	29421
Dog	uroporphyrinogen decarboxylase	VGNC:48169	475378

Species	Name	OMA	EggNOG	Inparanoid
Chimp	uroporphyrinogen decarboxylase
Macaque	uroporphyrinogen decarboxylase
Mouse	uroporphyrinogen decarboxylase
Rat	uroporphyrinogen decarboxylase
Dog	uroporphyrinogen decarboxylase

Protein Data Bank (19)

1 – 5 of 19

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (11)

Reactome (3)

KEGG (2)

PathwayCommons (4)

UniProt (1)

WikiPathways (1)

Heme biosynthesis (R-HSA-189451)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Heme biosynthesis	11 targets	R-HSA-189451
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of porphyrins	16 targets	R-HSA-189445

Name	Explore in Pharos	Explore in Source
Heme biosynthesis	11 targets	R-HSA-189451
Metabolism	2112 targets	R-HSA-1430728
Metabolism of porphyrins	16 targets	R-HSA-189445

Gene Ontology Terms (5)

Functions (1)

Components (2)

Processes (2)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
uroporphyrinogen decarboxylase activity	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (173)

Explore Interacting Targets

1 – 10 of 173

• See Interactions on String-DB

PPID

Tchem

Family: Enzyme

Novelty: 0.01068886

p_int: 0.980868418

p_ni: 0.019131581

Score: 0.359

Data Source: BioPlex,STRINGDB

POTEF

Tbio

Novelty: 0.00191599

p_int: 0.939611779

p_ni: 0.060388221

Score: 0.272

Data Source: BioPlex,STRINGDB

CPNE5

Tbio

Novelty: 0.09416684

p_int: 0.857628432

p_ni: 0.142371567

p_wrong: 1e-9

Score: 0.189

Data Source: BioPlex,STRINGDB

CPOX

Tbio

Family: Enzyme

Novelty: 0.01097519

Score: 0.998

Data Source: STRINGDB

UROS

Tbio

Family: Enzyme

Novelty: 0.00938683

Score: 0.994

Data Source: STRINGDB

HMBS

Tbio

Family: Enzyme

Novelty: 0.00193847

Score: 0.993

Data Source: STRINGDB

PPOX

Tchem

Family: Enzyme

Novelty: 0.00652809

Score: 0.993

Data Source: STRINGDB

ALAD

Tbio

Family: Enzyme

Novelty: 0.00092757

Score: 0.961

Data Source: STRINGDB

FECH

Tbio

Family: Enzyme

Novelty: 0.00282289

Score: 0.947

Data Source: STRINGDB

FAM84B

Tbio

Novelty: 0.10702561

Score: 0.766

Data Source: STRINGDB

Publication Statistics

PubMed Score  298.58

PubMed score by year

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PubTator Score  336.98

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Complete proteome
Cytoplasm
Decarboxylase
Direct protein sequencing
Disease mutation
Heme biosynthesis
Lyase
Porphyrin biosynthesis

MGI Phenotype Find Similar Targets

mortality/aging