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Tbio
UROD
Uroporphyrinogen decarboxylase

Protein Summary
Description
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
histone modification site profile
0.9
transcription factor perturbation
0.88
transcription factor binding site profile
0.74
tissue sample
0.7


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.58   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.58   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uroporphyrinogen decarboxylase
VGNC:1719
456541
Macaque
uroporphyrinogen decarboxylase
705166
Mouse
MGI:98916
22275
Rat
RGD:3946
29421
Dog
uroporphyrinogen decarboxylase
VGNC:48169
475378
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uroporphyrinogen decarboxylase
Macaque
uroporphyrinogen decarboxylase
Mouse
Rat
Dog
uroporphyrinogen decarboxylase
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Heme biosynthesis (R-HSA-189451)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme biosynthesis
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme biosynthesis
Metabolism
Metabolism of porphyrins
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (173)
1 – 10 of 173
PPID
Tchem
Family: Enzyme
Novelty: 0.01068886
p_int: 0.980868418
p_ni: 0.019131581
Score: 0.359
Data Source: BioPlex,STRINGDB
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.939611779
p_ni: 0.060388221
Score: 0.272
Data Source: BioPlex,STRINGDB
CPNE5
Tbio
Novelty: 0.09416684
p_int: 0.857628432
p_ni: 0.142371567
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
CPOX
Tbio
Family: Enzyme
Novelty: 0.01097519
Score: 0.998
Data Source: STRINGDB
UROS
Tbio
Family: Enzyme
Novelty: 0.00938683
Score: 0.994
Data Source: STRINGDB
HMBS
Tbio
Family: Enzyme
Novelty: 0.00193847
Score: 0.993
Data Source: STRINGDB
PPOX
Tchem
Family: Enzyme
Novelty: 0.00652809
Score: 0.993
Data Source: STRINGDB
ALAD
Tbio
Family: Enzyme
Novelty: 0.00092757
Score: 0.961
Data Source: STRINGDB
FECH
Tbio
Family: Enzyme
Novelty: 0.00282289
Score: 0.947
Data Source: STRINGDB
FAM84B
Tbio
Novelty: 0.10702561
Score: 0.766
Data Source: STRINGDB
Publication Statistics
PubMed Score  298.58

PubMed score by year
PubTator Score  336.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer