Tbio CD5 T-cell surface glycoprotein CD5

Protein Summary

Description

May act as a receptor in regulating T-cell proliferation. This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• P06127
• A0N0P4
• A8K9I3

Gene Name

• CD5

Ensembl ID

• ENST00000347785
• ENSP00000342681
• ENSG00000110448

Symbol

• LEU1
• T1
• LEU1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.88
cell type or tissue	0.85
gene perturbation	0.82
hub protein	0.82
cell line	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3295.05   (req: < 5)

Gene RIFs: 80   (req: <= 3)

Antibodies: 3371   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3295.05   (req: >= 5)

Gene RIFs: 80   (req: > 3)

Antibodies: 3371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0