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Tbio
COL5A2
Collagen alpha-2(V) chain

Protein Summary
Description
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374866
  • ENSP00000364000
  • ENSG00000204262
  • ENST00000649066
  • ENSP00000497741

Symbol
  • EDSC
  • EDSCL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
gene perturbation
0.99
transcription factor perturbation
0.94
small molecule perturbation
0.82
kinase perturbation
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.31   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.31   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88458
12832
Rat
RGD:70921
85250
Dog
collagen type V alpha 2 chain
VGNC:39478
478836
Horse
collagen type V alpha 2 chain
VGNC:16745
100054421
Opossum
collagen type V alpha 2 chain
100028445
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
collagen type V alpha 2 chain
Horse
collagen type V alpha 2 chain
Opossum
collagen type V alpha 2 chain
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05997-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (64)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (137)
1 – 10 of 137
LAIR2
Tbio
Novelty: 0.06117644
p_int: 0.99999993
p_wrong: 7e-8
Data Source: BioPlex
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.996
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.994
Data Source: STRINGDB
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.993
Data Source: STRINGDB
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
Score: 0.974
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.972
Data Source: STRINGDB
COL6A3
Tbio
Novelty: 0.00805254
Score: 0.971
Data Source: STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
Score: 0.969
Data Source: STRINGDB
ADAMTS2
Tbio
Family: Enzyme
Novelty: 0.00852208
Score: 0.968
Data Source: STRINGDB
COL12A1
Tbio
Novelty: 0.0239421
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.31

PubMed score by year
PubTator Score  69.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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