Tbio COL5A2 Collagen alpha-2(V) chain

Protein Summary

Description

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P05997
• P78440
• Q13908
• Q53WR4
• Q59GR4
• Q6LDJ5
• Q7KZ55
• Q86XF6
• Q96QB0
• Q96QB3

Gene Name

• COL5A2

Ensembl ID

• ENST00000374866
• ENSP00000364000
• ENSG00000204262
• ENST00000649066
• ENSP00000497741

Symbol

• EDSC
• EDSCL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
gene perturbation	0.99
transcription factor perturbation	0.94
small molecule perturbation	0.82
kinase perturbation	0.76

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.31   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.31   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	collagen, type V, alpha 2	MGI:88458	12832
Rat	collagen type V alpha 2 chain	RGD:70921	85250
Dog	collagen type V alpha 2 chain	VGNC:39478	478836
Horse	collagen type V alpha 2 chain	VGNC:16745	100054421
Opossum	collagen type V alpha 2 chain		100028445

Species	Name	OMA	EggNOG	Inparanoid
Mouse	collagen, type V, alpha 2
Rat	collagen type V alpha 2 chain
Dog	collagen type V alpha 2 chain
Horse	collagen type V alpha 2 chain
Opossum	collagen type V alpha 2 chain

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05997-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (64)

Reactome (5)

KEGG (1)

PathwayCommons (5)

WikiPathways (53)

Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

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Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Reactome	Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Reactome	Collagen chain trimerization	44 targets	R-HSA-8948216
Reactome	Collagen formation	90 targets	R-HSA-1474290
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Collagen chain trimerization	44 targets	R-HSA-8948216
Collagen formation	90 targets	R-HSA-1474290
Extracellular matrix organization	297 targets	R-HSA-1474244

Gene Ontology Terms (20)

Functions (4)

Components (7)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
extracellular matrix structural constituent conferring tensile strength	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
extracellular matrix structural constituent	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
SMAD binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (137)

Explore Interacting Targets

1 – 10 of 137

• See Interactions on String-DB

LAIR2

Tbio

Novelty: 0.06117644

p_int: 0.99999993

p_wrong: 7e-8

Data Source: BioPlex

COL1A2

Tbio

Novelty: 0.00048334

Score: 0.996

Data Source: STRINGDB

COL1A1

Tbio

Novelty: 0.00063584

Score: 0.994

Data Source: STRINGDB

COL3A1

Tbio

Novelty: 0.00197327

Score: 0.993

Data Source: STRINGDB

PLOD1

Tbio

Family: Enzyme

Novelty: 0.00905345

Score: 0.974

Data Source: STRINGDB

COL5A1

Tbio

Novelty: 0.00506815

Score: 0.972

Data Source: STRINGDB

COL6A3

Tbio

Novelty: 0.00805254

Score: 0.971

Data Source: STRINGDB

COL4A1

Tbio

Novelty: 0.00358049

Score: 0.969

Data Source: STRINGDB

ADAMTS2

Tbio

Family: Enzyme

Novelty: 0.00852208

Score: 0.968

Data Source: STRINGDB

COL12A1

Tbio

Novelty: 0.0239421

Score: 0.968

Data Source: STRINGDB

Publication Statistics

PubMed Score  68.31

PubMed score by year

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PubTator Score  69.23

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Calcium
Collagen
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Ehlers-Danlos syndrome
Extracellular matrix
Glycoprotein

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
growth/size/body region phenotype
integument phenotype
mortality/aging
respiratory system phenotype
skeleton phenotype
vision/eye phenotype