Tchem HPN Serine protease hepsin

Protein Summary

Description

Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• P05981
• B2RDS4

Gene Name

• HPN

Ensembl ID

• ENST00000262626
• ENSP00000262626
• ENSG00000105707
• ENST00000392226
• ENSP00000376060

Symbol

• TMPRSS1
• TMPRSS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
molecular function	0.96
gene perturbation	0.91
disease perturbation	0.9
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Serine Protease Hepsin

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Serine Protease Hepsin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.04   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.04   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6