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Tchem
HPN
Serine protease hepsin

Protein Summary
Description
Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890). This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262626
  • ENSP00000262626
  • ENSG00000105707
  • ENST00000392226
  • ENSP00000376060

Symbol
  • TMPRSS1
  • TMPRSS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.96
gene perturbation
0.91
disease perturbation
0.9
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.41   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.41   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 90
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
8
10
99.4
calcium measurement
1
5
5
97.6
blood protein measurement
2
4
4
96.9
sex hormone-binding globulin measurement
6
2
6
94.7
triglyceride measurement
4
4
5
92
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
10
99.4
calcium measurement
5
97.6
blood protein measurement
4
96.9
sex hormone-binding globulin measurement
6
94.7
triglyceride measurement
5
92
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hepsin
VGNC:2354
455944
Macaque
hepsin
707242
Mouse
MGI:1196620
15451
Rat
RGD:61982
29135
Dog
hepsin
VGNC:41772
484583
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hepsin
Macaque
hepsin
Mouse
Rat
Dog
hepsin
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05981-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
MET Receptor Activation (R-HSA-6806942)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET Receptor Activation
Reactome
Signal Transduction
Reactome
Signaling by MET
Reactome
Signaling by MST1
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
MET Receptor Activation
Signal Transduction
Signaling by MET
Signaling by MST1
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (32)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (33)
1 – 10 of 33
HGF
Tchem
Family:  Enzyme
Novelty:  0.00035574
Score:  0.946
Data Source:  Reactome,STRINGDB
MST1
Tchem
Family:  Enzyme
Novelty:  0.00781564
Score:  0.916
Data Source:  Reactome,STRINGDB
SPINT1
Tbio
Family:  Enzyme
Novelty:  0.00930324
Score:  0.781
Data Source:  STRINGDB
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
Score:  0.703
Data Source:  STRINGDB
AMACR
Tbio
Family:  Enzyme
Novelty:  0.00218306
Score:  0.69
Data Source:  STRINGDB
GRAMD1A
Tbio
Novelty:  0.15461113
Score:  0.639
Data Source:  STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.54
Data Source:  STRINGDB
F7
Tchem
Family:  Enzyme
Novelty:  0.0002521
Score:  0.529
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.527
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.524
Data Source:  STRINGDB
Publication Statistics
PubMed Score  151.41

PubMed score by year
PubTator Score  75.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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