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Tbio
CALB1
Calbindin

Protein Summary
Description
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265431
  • ENSP00000265431
  • ENSG00000104327
  • ENST00000518457
  • ENSP00000429602

Symbol
  • CAB27
  • CALB
  • D-28K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
virus perturbation
0.92
disease perturbation
0.74
disease
0.7
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2704.92   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 412   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2704.92   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 412   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (231)
PVALB
Tbio
Novelty:  0.00024439
Score:  0.945
Data Source:  STRINGDB
OSGIN2
Tbio
Novelty:  0.18268167
Score:  0.837
Data Source:  STRINGDB
SDF4
Tbio
Novelty:  0.00105893
Score:  0.836
Data Source:  STRINGDB
TRPV6
Tchem
Family:  IC
Novelty:  0.00383629
Score:  0.832
Data Source:  STRINGDB
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
Score:  0.821
Data Source:  STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.802
Data Source:  STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
Score:  0.802
Data Source:  STRINGDB
RBFOX3
Tbio
Novelty:  0.00038317
Score:  0.781
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.77
Data Source:  STRINGDB
S100G
Tbio
Novelty:  0.00314874
Score:  0.764
Data Source:  STRINGDB
Pathways (3)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
70.5
smoking status measurement
2
2
2
64
lymphocyte percentage of leukocytes
1
1
1
37.6
1
1
0
1.3
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
70.5
smoking status measurement
2
64
lymphocyte percentage of leukocytes
1
37.6
0
1.3
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calbindin 1
VGNC:915
464279
Macaque
calbindin
677721
Mouse
MGI:88248
12307
Rat
RGD:69340
83839
Dog
calbindin 1
VGNC:38660
611334
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calbindin 1
Macaque
calbindin
Mouse
Rat
Dog
calbindin 1
Publication Statistics
PubMed Score 2704.92
PubMed score by year
PubTator Score 424.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title