Protein Summary
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]
- ENST00000265431
- ENSP00000265431
- ENSG00000104327
- ENST00000518457
- ENSP00000429602
- CAB27
- CALB
- D-28K
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
virus perturbation | 0.92 | ||
disease perturbation | 0.74 | ||
disease | 0.7 | ||
microRNA | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2704.92 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 412 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2704.92 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 412 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (231)
Nearest Tclin Targets (2)
Upstream (2)
Pathways (3)
Reactome (2)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (5)
Components (15)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 1 | 2 | 70.5 | |||||
smoking status measurement | 2 | 2 | 2 | 64 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 37.6 | |||||
1 | 1 | 0 | 1.3 | 30.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 70.5 | |||||
smoking status measurement | 2 | 64 | |||||
lymphocyte percentage of leukocytes | 1 | 37.6 | |||||
0 | 1.3 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | calbindin 1 | VGNC:915 | 464279 | |||||
Macaque | calbindin | 677721 | ||||||
Mouse | MGI:88248 | 12307 | ||||||
Rat | RGD:69340 | 83839 | ||||||
Dog | calbindin 1 | VGNC:38660 | 611334 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | calbindin 1 | |||||
Macaque | calbindin | |||||
Mouse | ||||||
Rat | ||||||
Dog | calbindin 1 | |||||
Publication Statistics
PubMed Score 2704.92
PubMed score by year
PubTator Score 424.85
PubTator score by year
Related Publications
Text Mined References (49)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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