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Tbio
CSN2
Beta-casein

Protein Summary
Description
Important role in determination of the surface properties of the casein micelles. This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353151
  • ENSP00000341030
  • ENSG00000135222
  • ENST00000635174
  • ENSP00000489488
  • ENSG00000283030

Symbol
  • CASB
  • CASB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.54
cell type or tissue
0.53
disease
0.53
gene perturbation
0.49
hub protein
0.49


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2010.5   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2010.5   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
CORO2A
Tbio
Novelty:  0.03292199
p_int:  0.998388223
p_ni:  0.001611658
p_wrong:  1.19e-7
Score:  0.379
Data Source:  BioPlex,STRINGDB
PPP3CC
Tbio
Family:  Enzyme
Novelty:  0.02633046
p_int:  0.993326294
p_ni:  0.006673699
p_wrong:  7e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.978
Data Source:  STRINGDB
CSN3
Tbio
Family:  Enzyme
Novelty:  0.00059158
Score:  0.929
Data Source:  STRINGDB
CSN1S1
Tbio
Family:  Enzyme
Novelty:  0.00200522
Score:  0.91
Data Source:  STRINGDB
LALBA
Tbio
Family:  Enzyme
Novelty:  0.00037262
Score:  0.907
Data Source:  STRINGDB
PRL
Tbio
Novelty:  0.0000905
Score:  0.894
Data Source:  STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.793
Data Source:  STRINGDB
NEK9
Tchem
Family:  Kinase
Novelty:  0.02386353
Score:  0.721
Data Source:  STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
Score:  0.685
Data Source:  STRINGDB
Pathways (55)
Nuclear signaling by ERBB4 (R-HSA-1251985)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Nuclear signaling by ERBB4
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Nuclear signaling by ERBB4
Signal Transduction
Signaling by ERBB4
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
42.3
sex hormone-binding globulin measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
42.3
sex hormone-binding globulin measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
casein beta
VGNC:2031
741321
Macaque
casein beta
707520
Mouse
MGI:88541
12991
Rat
RGD:61981
29173
Dog
casein beta
VGNC:39665
403644
Species
Name
OMA
EggNOG
Inparanoid
Chimp
casein beta
Macaque
casein beta
Mouse
Rat
Dog
casein beta
Publication Statistics
PubMed Score 2010.50
PubMed score by year
PubTator Score 203.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title