Tbio KRT8 Keratin, type II cytoskeletal 8

Protein Summary

Description

Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P05787
• A8K4H3
• B0AZN5
• F8VXB4
• Q14099
• Q14716
• Q14717
• Q53GJ0
• Q6DHW5
• Q6GMY0
• Q6P4C7
• Q96J60

Gene Name

• KRT8

Ensembl ID

• ENST00000293308
• ENSP00000293308
• ENSG00000170421
• ENST00000546897
• ENSP00000447402
• ENST00000552150
• ENSP00000449404
• ENST00000552551
• ENSP00000447566

Symbol

• CYK8
• K8
• KO
• CK8
• CK-8
• CYK8
• K2C8
• CARD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.99
transcription factor perturbation	0.99
interacting protein	0.98
disease perturbation	0.97
hub protein	0.97

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1095.81   (req: < 5)

Gene RIFs: 123   (req: <= 3)

Antibodies: 3208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1095.81   (req: >= 5)

Gene RIFs: 123   (req: > 3)

Antibodies: 3208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0