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Tchem
PRKCB
Protein kinase C beta type

Protein Summary
Description
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303531
  • ENSP00000305355
  • ENSG00000166501
  • ENST00000321728
  • ENSP00000318315
  • ENST00000643927
  • ENSP00000496129
  • ENST00000646168
  • ENSP00000493817

Symbol
  • PKCB
  • PRKCB1
  • PKCB
  • PRKCB1
  • PRKCB2
  • PKCI(2)
  • PKCbeta
  • PKC-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
protein domain
1
biological process
0.99
biological term
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.81   (req: < 5)
Gene RIFs: 182   (req: <= 3)
Antibodies: 805   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.81   (req: >= 5)
Gene RIFs: 182   (req: > 3)
Antibodies: 805   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 228
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (228)
1 – 10 of 228
staurosporine
Rendered image for staurosporine
CHEMBL4576489
Rendered image for CHEMBL4576489
G&ouml; 6976
Rendered image for G&ouml; 6976
GSK690693
Rendered image for GSK690693
balanol
Rendered image for balanol
UCN-01
Rendered image for UCN-01
7-hydroxystaurosporine
Rendered image for 7-hydroxystaurosporine
sotrastaurin
Rendered image for sotrastaurin
Bisindolylmaleimide I
Rendered image for Bisindolylmaleimide I
Protein-Protein Interactions (281)
1 – 10 of 281
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
p_int:  1
Score:  0.937
Data Source:  BioPlex,STRINGDB
ECM1
Tbio
Novelty:  0.00518679
p_int:  0.810255757
p_ni:  0.188477582
p_wrong:  0.001266661
Data Source:  BioPlex
PRKCD
Tclin
Family:  Kinase
Novelty:  0.0009758
Score:  0.975
Data Source:  STRINGDB
MARCKS
Tbio
Family:  Enzyme
Novelty:  0.00171584
Score:  0.973
Data Source:  STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
Score:  0.973
Data Source:  STRINGDB
IKBKB
Tchem
Family:  Kinase
Novelty:  0.00090202
Score:  0.972
Data Source:  STRINGDB
CARD11
Tbio
Family:  Enzyme
Novelty:  0.00716457
Score:  0.967
Data Source:  STRINGDB
GRIA2
Tclin
Family:  IC
Novelty:  0.00141257
Score:  0.956
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.946
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.945
Data Source:  STRINGDB
Pathways (186)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 41
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
Beta-catenin independent WNT signaling
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
Beta-catenin independent WNT signaling
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
3
76.5
Mycobacterium avium complex disease
1
1
1
58.4
body mass index
1
2
2
42
2
1
0
1.1
35
primary biliary cirrhosis
1
1
0
1.3
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
76.5
Mycobacterium avium complex disease
1
58.4
body mass index
2
42
0
1.1
35
primary biliary cirrhosis
0
1.3
30.2
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase C beta
VGNC:8996
453993
Macaque
protein kinase C beta
701195
Mouse
MGI:97596
18751
Rat
RGD:3396
25023
Dog
protein kinase C beta
VGNC:49947
489968
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase C beta
Macaque
protein kinase C beta
Mouse
Rat
Dog
protein kinase C beta
Publication Statistics
PubMed Score 517.81
PubMed score by year
PubTator Score 487.35
PubTator score by year
Patents
Patents by year