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Tbio
SERPIND1
Heparin cofactor 2

Protein Summary
Description
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215727
  • ENSP00000215727
  • ENSG00000099937
  • ENST00000406799
  • ENSP00000384050

Symbol
  • HCF2
  • HC2
  • LS2
  • HCF2
  • HCII
  • HLS2
  • THPH10
  • D22S673
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
gene perturbation
0.71
kinase perturbation
0.6
molecular function
0.56
cell line
0.55


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 858.44   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 858.44   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family D member 1
VGNC:9953
745390
Macaque
serpin family D member 1
696950
Mouse
MGI:96051
15160
Rat
RGD:619854
79224
Dog
serpin family D member 1
VGNC:46035
100682658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family D member 1
Macaque
serpin family D member 1
Mouse
Rat
Dog
serpin family D member 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05546-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Metabolism of proteins
Protein-Protein Interactions (182)
1 – 10 of 182
VAT1L
Tdark
Family: Enzyme
Novelty: 0.45114244
p_int: 0.976147919
p_ni: 0.023852081
Score: 0.685
Data Source: BioPlex,STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.998
Data Source: Reactome,STRINGDB
ITIH2
Tbio
Novelty: 0.04886358
Score: 0.98
Data Source: STRINGDB
FGG
Tbio
Novelty: 0.00404457
Score: 0.979
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.975
Data Source: STRINGDB
FGB
Tbio
Novelty: 0.00437751
Score: 0.97
Data Source: STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.968
Data Source: STRINGDB
F10
Tclin
Family: Enzyme
Novelty: 0.00063008
Score: 0.965
Data Source: STRINGDB
AHSG
Tbio
Novelty: 0.00112502
Score: 0.964
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  858.44

PubMed score by year
PubTator Score  354.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer