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Tbio
SERPIND1
Heparin cofactor 2

Protein Summary
Description
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215727
  • ENSP00000215727
  • ENSG00000099937
  • ENST00000406799
  • ENSP00000384050

Symbol
  • HCF2
  • HC2
  • LS2
  • HCF2
  • HCII
  • HLS2
  • THPH10
  • D22S673
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
gene perturbation
0.71
kinase perturbation
0.6
molecular function
0.56
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 769.88   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 769.88   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Reactome
Intrinsic Pathway of Fibrin Clot Formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Intrinsic Pathway of Fibrin Clot Formation
Metabolism of proteins
Protein-Protein Interactions (182)
1 – 10 of 182
VAT1L
Tdark
Family: Enzyme
Novelty: 1.09090909
p_int: 0.976147919
p_ni: 0.023852081
Score: 0.685
Data Source: BioPlex,STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00006072
Score: 0.998
Data Source: Reactome,STRINGDB
ITIH2
Tbio
Novelty: 0.05422455
Score: 0.98
Data Source: STRINGDB
FGG
Tbio
Novelty: 0.00622014
Score: 0.979
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00122914
Score: 0.975
Data Source: STRINGDB
FGB
Tbio
Novelty: 0.00757235
Score: 0.97
Data Source: STRINGDB
APOA1
Tbio
Novelty: 0.0001431
Score: 0.968
Data Source: STRINGDB
F10
Tclin
Family: Enzyme
Novelty: 0.0007229
Score: 0.965
Data Source: STRINGDB
AHSG
Tbio
Novelty: 0.00097441
Score: 0.964
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00010107
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  769.88

PubMed score by year
PubTator Score  354.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer