You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HLA-DQB2
HLA class II histocompatibility antigen, DQ beta 2 chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399661
  • ENSP00000382569
  • ENSG00000196610
  • ENST00000411527
  • ENSP00000390431
  • ENSG00000232629
  • ENST00000426733
  • ENSP00000393969
  • ENSG00000226165
  • ENST00000430849
  • ENSP00000389067
  • ENSG00000228813
  • ENST00000432486
  • ENSP00000410132
  • ENSG00000228254
  • ENST00000438757
  • ENSP00000408884
  • ENSG00000224305
  • ENST00000456529
  • ENSP00000399594
  • ENSG00000230675
  • ENST00000457432
  • ENSP00000396502
  • ENSG00000229493

Symbol
  • HLA-DXB
  • DQB2
  • HLA-DXB
  • HLA-DQB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
phenotype
0.82
cellular component
0.78
trait
0.75
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.34   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.34   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (300)
PRL
Tbio
Novelty:  0.0000905
p_int:  0.994721686
p_ni:  0.004517483
p_wrong:  0.00076083
Score:  0.689
Data Source:  BioPlex,STRINGDB
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.980509794
p_ni:  0.019490206
Score:  0.177
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.920256377
p_ni:  0.079743623
Score:  0.152
Data Source:  BioPlex,STRINGDB
COL14A1
Tbio
Novelty:  0.01760399
p_int:  0.867401613
p_ni:  0.132598387
Score:  0.179
Data Source:  BioPlex,STRINGDB
PRPS2
Tbio
Family:  Kinase
Novelty:  0.02472415
p_int:  0.77691088
p_ni:  0.22308912
Score:  0.197
Data Source:  BioPlex,STRINGDB
CD74
Tchem
Novelty:  0.00281228
Score:  0.995
Data Source:  STRINGDB
HLA-DQA1
Tbio
Novelty:  0.00077488
Score:  0.989
Data Source:  STRINGDB
HLA-DQA2
Tbio
Novelty:  0.00431613
Score:  0.989
Data Source:  STRINGDB
HLA-DMA
Tbio
Novelty:  0.00405566
Score:  0.969
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1043)
Items per page:
1 – 5 of 1043
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
8
0
2.4
99.4
7
8
0
2.4
99.4
7
8
0
2.4
99.4
7
8
0
2.4
99.4
7
8
0
2.4
99.4
Items per page:
1 – 5 of 1043
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.4
99.4
0
2.4
99.4
0
2.4
99.4
0
2.4
99.4
0
2.4
99.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
HLA class II histocompatibility antigen, DQ beta 1 chain
100060531
Species
Name
OMA
EggNOG
Inparanoid
Horse
HLA class II histocompatibility antigen, DQ beta 1 chain
Publication Statistics
PubMed Score 13.34
PubMed score by year
PubTator Score 7.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title