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Tbio
ATP5MC1
ATP synthase F(0) complex subunit C1, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355938
  • ENSP00000348205
  • ENSG00000159199
  • ENST00000393366
  • ENSP00000377033

Symbol
  • ATP5G1
  • ATP5A
  • ATP5G
  • ATP5G1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (234)
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
p_int:  0.99713793
p_ni:  0.002853397
p_wrong:  0.000008674
Data Source:  BioPlex
BRINP2
Tdark
Novelty:  0.5101917
p_int:  0.996624744
p_ni:  0.003375251
p_wrong:  5e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.99585153
p_ni:  0.004148452
p_wrong:  1.8e-8
Score:  0.509
Data Source:  BioPlex,STRINGDB
BTN3A2
Tbio
Novelty:  0.06889505
p_int:  0.993855223
p_ni:  0.006144769
p_wrong:  8e-9
Score:  0.267
Data Source:  BioPlex,STRINGDB
B4GALT3
Tbio
Family:  Enzyme
Novelty:  0.04015046
p_int:  0.99292798
p_ni:  0.007072019
p_wrong:  2e-9
Score:  0.656
Data Source:  BioPlex,STRINGDB
TNFSF11
Tclin
Novelty:  0.00018328
p_int:  0.988026321
p_ni:  0.011973653
p_wrong:  2.6e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.985240569
p_ni:  0.014755544
p_wrong:  0.000003887
Data Source:  BioPlex
DPP6
Tbio
Family:  Enzyme
Novelty:  0.00435138
p_int:  0.954127157
p_ni:  0.045695151
p_wrong:  0.000177692
Data Source:  BioPlex
FUT3
Tbio
Family:  Enzyme
Novelty:  0.0059835
p_int:  0.907516793
p_ni:  0.092483024
p_wrong:  1.83e-7
Data Source:  BioPlex
ATP5MC3
Tdark
Family:  Enzyme
Novelty:  0.04850603
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial protein import
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Mitochondrial protein import
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
3
1.1
94.4
alkaline phosphatase measurement
2
2
2
6.6
80
body height
2
2
2
78.7
BMI-adjusted hip circumference
2
3
3
64.3
platelet crit
1
1
1
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
94.4
alkaline phosphatase measurement
2
6.6
80
body height
2
78.7
BMI-adjusted hip circumference
3
64.3
platelet crit
1
64
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase membrane subunit c locus 1
VGNC:53297
455195
Macaque
ATP synthase membrane subunit c locus 1
697950
Macaque
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)-like
707476
Mouse
MGI:107653
11951
Rat
RGD:61933
29754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase membrane subunit c locus 1
Macaque
ATP synthase membrane subunit c locus 1
Macaque
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)-like
Mouse
Rat
Publication Statistics
PubMed Score 25.39
PubMed score by year
PubTator Score 26.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title