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Tbio
POLR3D
DNA-directed RNA polymerase III subunit RPC4

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306433
  • ENSP00000303088
  • ENSG00000168495
  • ENST00000397802
  • ENSP00000380904

Symbol
  • BN51
  • BN51T
  • RPC4
  • BN51T
  • RPC53
  • TSBN51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
histone modification site profile
0.91
kinase perturbation
0.91
virus perturbation
0.88
transcription factor binding site profile
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.79   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.79   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit D
VGNC:10222
464043
Macaque
RNA polymerase III subunit D
707923
Mouse
MGI:1914315
67065
Rat
RGD:1311816
306012
Dog
RNA polymerase III subunit D
VGNC:44803
100856457
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase III subunit D
Macaque
RNA polymerase III subunit D
Mouse
Rat
Dog
RNA polymerase III subunit D
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P05423-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Gene expression (Transcription)
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Gene expression (Transcription)
Immune System
Innate Immune System
RNA Polymerase III Abortive And Retractive Initiation
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (218)
1 – 10 of 218
POLR3E
Tbio
Family: Enzyme
Novelty: 0.06500715
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
POLR1C
Tbio
Family: Enzyme
Novelty: 0.04485332
p_int: 0.999999995
p_ni: 5e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3F
Tbio
Family: Enzyme
Novelty: 0.0805125
p_int: 0.999999979
p_ni: 2e-8
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CRCP
Tbio
Family: Enzyme
Novelty: 0.01111812
p_int: 0.999999875
p_ni: 1.21e-7
p_wrong: 4e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
POLR3GL
Tdark
Family: Enzyme
Novelty: 0.35648533
p_int: 0.999999785
p_ni: 2.15e-7
Score: 0.989
Data Source: BioPlex,STRINGDB
POLR3C
Tbio
Family: Enzyme
Novelty: 0.05778457
p_int: 0.999999613
p_ni: 3.87e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
POLR3H
Tbio
Family: Enzyme
Novelty: 0.16483597
p_int: 0.999999533
p_ni: 3.81e-7
p_wrong: 8.6e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
GPN3
Tbio
Family: Enzyme
Novelty: 0.13817794
p_int: 0.999998614
p_ni: 0.000001386
Score: 0.795
Data Source: BioPlex,STRINGDB
POLR3G
Tbio
Family: Enzyme
Novelty: 0.04923071
p_int: 0.99999467
p_ni: 6e-9
p_wrong: 0.000005324
Score: 0.994
Data Source: BioPlex,STRINGDB
POLR3K
Tbio
Family: Enzyme
Novelty: 0.07105011
p_int: 0.9999942
p_ni: 0.000005686
p_wrong: 1.15e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  34.79

PubMed score by year
PubTator Score  9.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer