FABP3
Fatty acid-binding protein, heart
Protein Summary
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
- ENST00000373713
- ENSP00000362817
- ENSG00000121769
- FABP11
- MDGI
- MDGI
- FABP11
- H-FABP
- M-FABP
- O-FABP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.97 | ||
gene perturbation | 0.74 | ||
molecular function | 0.7 | ||
biological process | 0.67 | ||
disease | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 868.6 (req: < 5)
Gene RIFs: 113 (req: <= 3)
Antibodies: 1051 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 868.6 (req: >= 5)
Gene RIFs: 113 (req: > 3)
Antibodies: 1051 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 32
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2