Protein Summary
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
- ENST00000371222
- ENSP00000360266
- ENSG00000177606
- AP1
- p39
- AP-1
- c-Jun
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
drug perturbation | 1 | ||
hub protein | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12960.75 (req: < 5)
Gene RIFs: 726 (req: <= 3)
Antibodies: 3423 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12960.75 (req: >= 5)
Gene RIFs: 726 (req: > 3)
Antibodies: 3423 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 80
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 55
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (55)
Protein-Protein Interactions (945)
FOS
Family: TF
Novelty: 0.00006103
p_int: 0.9999958
p_ni: 0.0000042
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FOSL2
Family: TF
Novelty: 0.00375452
p_int: 0.999995346
p_ni: 0.000004654
Score: 0.996
Data Source: BioPlex,STRINGDB
ATF2
Family: TF
Novelty: 0.00457832
p_int: 0.999971494
p_ni: 0.000025679
p_wrong: 0.000002827
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
BATF3
Family: TF
Novelty: 0.01554987
p_int: 0.999968347
p_ni: 0.000031652
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
PPP2R2D
Family: Enzyme
Novelty: 0.0658328
p_int: 0.999947452
p_ni: 0.000046667
p_wrong: 0.000005881
Score: 0.153
Data Source: BioPlex,STRINGDB
RALBP1
Novelty: 0.01525176
p_int: 0.999728618
p_ni: 0.000271382
p_wrong: 1e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
ARIH1
Family: Enzyme
Novelty: 0.0258739
p_int: 0.99953628
p_ni: 0.000463719
p_wrong: 1e-9
Data Source: BioPlex
CREB5
Family: TF
Novelty: 0.03857106
p_int: 0.998985126
p_ni: 0.001014874
Score: 0.922
Data Source: BioPlex,STRINGDB
JUNB
Family: TF
Novelty: 0.00841656
p_int: 0.99885311
p_ni: 0.001146849
p_wrong: 4.2e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
ARHGAP22
Family: Enzyme
Novelty: 0.13037853
p_int: 0.998556272
p_ni: 0.001443728
Data Source: BioPlex
Nearest Tclin Targets (11)
Upstream (2)
Downstream (9)
Pathways (266)
Reactome (55)
KEGG (50)
PathwayCommons (90)
WikiPathways (71)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Activation of the AP-1 family of transcription factors | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Activation of the AP-1 family of transcription factors | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (89)
Functions (23)
Components (9)
Processes (57)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:96646 | 16476 | ||||||
Rat | RGD:2943 | 24516 | ||||||
Dog | Jun proto-oncogene, AP-1 transcription factor subunit | VGNC:42197 | 609429 | |||||
Cow | Jun proto-oncogene, AP-1 transcription factor subunit | VGNC:30386 | 280831 | |||||
Opossum | Jun proto-oncogene, AP-1 transcription factor subunit | 100018774 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | Jun proto-oncogene, AP-1 transcription factor subunit | |||||
Cow | Jun proto-oncogene, AP-1 transcription factor subunit | |||||
Opossum | Jun proto-oncogene, AP-1 transcription factor subunit | |||||
Publication Statistics
PubMed Score 12960.75
PubMed score by year
PubTator Score 3846.45
PubTator score by year
Related Publications
Text Mined References (916)
GeneRif Annotations (726)
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