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Tchem
JUN
Transcription factor AP-1

Protein Summary
Description
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371222
  • ENSP00000360266
  • ENSG00000177606

Symbol
  • AP1
  • p39
  • AP-1
  • c-Jun
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
drug perturbation
1
hub protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12698.76   (req: < 5)
Gene RIFs: 726   (req: <= 3)
Antibodies: 3423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12698.76   (req: >= 5)
Gene RIFs: 726   (req: > 3)
Antibodies: 3423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 80
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (266)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 55
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activation of the AP-1 family of transcription factors
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (89)
Items per page:
10
1 – 10 of 23
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (945)
1 – 10 of 945
FOS
Tbio
Family: TF
Novelty: 0.00006103
p_int: 0.9999958
p_ni: 0.0000042
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FOSL2
Tbio
Family: TF
Novelty: 0.00375452
p_int: 0.999995346
p_ni: 0.000004654
Score: 0.996
Data Source: BioPlex,STRINGDB
ATF2
Tbio
Family: TF
Novelty: 0.00457832
p_int: 0.999971494
p_ni: 0.000025679
p_wrong: 0.000002827
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
BATF3
Tbio
Family: TF
Novelty: 0.01554987
p_int: 0.999968347
p_ni: 0.000031652
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.999947452
p_ni: 0.000046667
p_wrong: 0.000005881
Score: 0.153
Data Source: BioPlex,STRINGDB
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.999728618
p_ni: 0.000271382
p_wrong: 1e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.99953628
p_ni: 0.000463719
p_wrong: 1e-9
Data Source: BioPlex
CREB5
Tbio
Family: TF
Novelty: 0.03857106
p_int: 0.998985126
p_ni: 0.001014874
Score: 0.922
Data Source: BioPlex,STRINGDB
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 0.99885311
p_ni: 0.001146849
p_wrong: 4.2e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
ARHGAP22
Tbio
Family: Enzyme
Novelty: 0.13037853
p_int: 0.998556272
p_ni: 0.001443728
Data Source: BioPlex
Publication Statistics
PubMed Score  12698.76

PubMed score by year
PubTator Score  3846.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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