Tchem JUN Transcription factor AP-1

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Transcription Factor Ap-1

Protein / Nucleic Acid Binding / Transcription Factor Ap-1

Protein Summary

Description

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P05412
• Q6FHM7
• Q96G93

Gene Name

• JUN

Ensembl ID

• ENST00000371222
• ENSP00000360266
• ENSG00000177606

Symbol

• AP1
• p39
• AP-1
• c-Jun

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
drug perturbation	1
hub protein	1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6471.97   (req: < 5)

Gene RIFs: 726   (req: <= 3)

Antibodies: 3423   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6471.97   (req: >= 5)

Gene RIFs: 726   (req: > 3)

Antibodies: 3423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 80

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (55)

Explore Active Ligands

1 – 10 of 55

CHEMBL424872

JUNTchem TF

EC50: 6.5

CHEMBL336546

JUNTchem TF

IC50: 7.3

CHEMBL245733

JUNTchem TF

IC50: 6.09

CHEMBL248176

JUNTchem TF

IC50: 6.15

CHEMBL1761564

JUNTchem TF

IC50: 6.48

CHEMBL1761569

JUNTchem TF

IC50: 6.7

CHEMBL129857

JUNTchem TF

IC50: 8.1

CHEMBL393659

JUNTchem TF

IC50: 6.13

CHEMBL423150

JUNTchem TF

IC50: 6.4

CHEMBL340779

JUNTchem TF

IC50: 6.7

Protein Data Bank (8)

1 – 5 of 8

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (266)

Reactome (55)

KEGG (50)

PathwayCommons (90)

WikiPathways (71)

Activation of HOX genes during differentiation (R-HSA-5619507)

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Items per page:

5

1 – 5 of 55

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Activation of the AP-1 family of transcription factors	10 targets	R-HSA-450341
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Activation of the AP-1 family of transcription factors	10 targets	R-HSA-450341
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Gene Ontology Terms (89)

Functions (23)

Components (9)

Processes (57)

Find Similar Targets

Items per page:

10

1 – 10 of 23

GO Term	Evidence	Assigned by
cAMP response element binding	Inferred from Direct Assay (IDA)	BHF-UCL
DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	BHF-UCL
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	BHF-UCL
GTPase activator activity	Inferred from Direct Assay (IDA)	UniProtKB
protein heterodimerization activity	Inferred from Direct Assay (IDA)	CAFA
protein homodimerization activity	Inferred from Direct Assay (IDA)	CAFA
RNA polymerase II distal enhancer sequence-specific DNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
transcription coactivator activity	Inferred from Direct Assay (IDA)	UniProtKB
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (945)

Explore Interacting Targets

1 – 10 of 945

• See Interactions on String-DB

FOS

Tbio

Family: TF

Novelty: 0.00007002

p_int: 0.9999958

p_ni: 0.0000042

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

FOSL2

Tbio

Family: TF

Novelty: 0.006377

p_int: 0.999995346

p_ni: 0.000004654

Score: 0.996

Data Source: BioPlex,STRINGDB

ATF2

Tbio

Family: TF

Novelty: 0.00562547

p_int: 0.999971494

p_ni: 0.000025679

p_wrong: 0.000002827

Score: 0.992

Data Source: BioPlex,Reactome,STRINGDB

BATF3

Tbio

Family: TF

Novelty: 0.01678998

p_int: 0.999968347

p_ni: 0.000031652

p_wrong: 1e-9

Score: 0.991

Data Source: BioPlex,STRINGDB

PPP2R2D

Tbio

Family: Enzyme

Novelty: 0.10054323

p_int: 0.999947452

p_ni: 0.000046667

p_wrong: 0.000005881

Score: 0.153

Data Source: BioPlex,STRINGDB

RALBP1

Tbio

Novelty: 0.0094994

p_int: 0.999728618

p_ni: 0.000271382

p_wrong: 1e-9

Score: 0.239

Data Source: BioPlex,STRINGDB

ARIH1

Tbio

Family: Enzyme

Novelty: 0.00502889

p_int: 0.99953628

p_ni: 0.000463719

p_wrong: 1e-9

Data Source: BioPlex

CREB5

Tbio

Family: TF

Novelty: 0.09663345

p_int: 0.998985126

p_ni: 0.001014874

Score: 0.922

Data Source: BioPlex,STRINGDB

JUNB

Tbio

Family: TF

Novelty: 0.01119828

p_int: 0.99885311

p_ni: 0.001146849

p_wrong: 4.2e-8

Score: 0.982

Data Source: BioPlex,STRINGDB

ARHGAP22

Tbio

Family: Enzyme

Novelty: 0.20584913

p_int: 0.998556272

p_ni: 0.001443728

Data Source: BioPlex

Publication Statistics

PubMed Score  6471.97

PubMed score by year

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PubTator Score  3846.45

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Acetylation
Activator
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Isopeptide bond
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hematopoietic system phenotype
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