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Tbio
RPLP0
60S acidic ribosomal protein P0

Protein Summary
Description
Ribosomal protein P0 is the functional equivalent of E.coli protein L10. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pse ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228306
  • ENSP00000339027
  • ENSG00000089157
  • ENST00000313104
  • ENSP00000366471
  • ENST00000392514
  • ENSP00000376299
  • ENST00000551150
  • ENSP00000449328

Symbol
  • P0
  • LP0
  • L10E
  • RPP0
  • PRLP0
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
0.98
gene perturbation
0.96


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.54   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.54   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
60S acidic ribosomal protein P0-like
744940
Macaque
ribosomal protein lateral stalk subunit P0
574363
Rat
RGD:621247
64205
Dog
ribosomal protein lateral stalk subunit P0
609159
Cow
ribosomal protein lateral stalk subunit P0
286868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
60S acidic ribosomal protein P0-like
Macaque
ribosomal protein lateral stalk subunit P0
Rat
Dog
ribosomal protein lateral stalk subunit P0
Cow
ribosomal protein lateral stalk subunit P0
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05388-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (41)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Cytokine Signaling in Immune system
Developmental Biology
Disease
Protein-Protein Interactions (578)
1 – 10 of 578
CCNDBP1
Tbio
Novelty: 0.01527762
p_int: 0.999999993
p_ni: 7e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
TUBA8
Tbio
Novelty: 0.06454549
p_int: 0.999999816
p_ni: 1.84e-7
Score: 0.606
Data Source: BioPlex,STRINGDB
CNBP
Tbio
Novelty: 0.00404247
p_int: 0.987833338
p_ni: 0.012166662
Score: 0.575
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.937364701
p_ni: 0.062635299
Score: 0.547
Data Source: BioPlex,STRINGDB
RPL8
Tbio
Novelty: 0.01064076
p_int: 0.936121152
p_ni: 0.063878848
Score: 0.999
Data Source: BioPlex,STRINGDB
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.930282735
p_ni: 0.069717265
Score: 0.999
Data Source: BioPlex,STRINGDB
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.929304405
p_ni: 0.070695595
Score: 0.641
Data Source: BioPlex,STRINGDB
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.91224718
p_ni: 0.08775282
Score: 0.813
Data Source: BioPlex,STRINGDB
BHLHA15
Tbio
Family: TF
Novelty: 0.02721846
p_int: 0.864007719
p_ni: 0.135992281
Data Source: BioPlex
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.847815447
p_ni: 0.152184553
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  169.54

PubMed score by year
PubTator Score  34.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer