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Tbio
RPLP2
60S acidic ribosomal protein P2

Protein Summary
Description
Plays an important role in the elongation step of protein synthesis. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P1. The P2 protein can interact with P0 and P1 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are mul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321153
  • ENSP00000322419
  • ENSG00000177600
  • ENST00000530797
  • ENSP00000431240

Symbol
  • D11S2243E
  • RPP2
  • P2
  • LP2
  • RPP2
  • D11S2243E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
kinase perturbation
1
transcription factor binding site profile
0.94
hub protein
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.81   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 306.81   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
5
6
91.5
mean platelet volume
2
2
2
89.4
intraocular pressure measurement
2
3
3
89
waist-hip ratio
4
6
9
86.9
Keratoconus
2
2
1
6.6
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
91.5
mean platelet volume
2
89.4
intraocular pressure measurement
3
89
waist-hip ratio
9
86.9
Keratoconus
1
6.6
82.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein lateral stalk subunit P2
VGNC:12802
450936
Macaque
ribosomal protein lateral stalk subunit P2
700698
Mouse
MGI:1914436
67186
Rat
RGD:621775
140662
Dog
ribosomal protein lateral stalk subunit P2
475991
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein lateral stalk subunit P2
Macaque
ribosomal protein lateral stalk subunit P2
Mouse
Rat
Dog
ribosomal protein lateral stalk subunit P2
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P05387-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Protein-Protein Interactions (409)
1 – 10 of 409
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.986559024
p_ni:  0.013440976
Score:  0.447
Data Source:  BioPlex,STRINGDB
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.984156318
p_ni:  0.015843682
Score:  0.329
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.974148893
p_ni:  0.025851107
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.965234546
p_ni:  0.034765454
Score:  0.999
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.95597284
p_ni:  0.04402716
Data Source:  BioPlex
SART3
Tbio
Novelty:  0.02353492
p_int:  0.928237536
p_ni:  0.071762464
Data Source:  BioPlex
RPL8
Tbio
Novelty:  0.01064076
p_int:  0.902650494
p_ni:  0.097349506
Score:  0.999
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.878062799
p_ni:  0.121937201
Data Source:  BioPlex
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.864652022
p_ni:  0.135347978
Score:  0.357
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.848115421
p_ni:  0.151884579
Data Source:  BioPlex
Publication Statistics
PubMed Score  306.81

PubMed score by year
PubTator Score  55.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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