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Tchem
ICAM1
Intercellular adhesion molecule 1

Protein Summary
Description
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264832
  • ENSP00000264832
  • ENSG00000090339

Symbol
  • BB2
  • CD54
  • P3.58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
transcription factor perturbation
0.98
virus perturbation
0.95
gene perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10458.29   (req: < 5)
Gene RIFs: 923   (req: <= 3)
Antibodies: 2725   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10458.29   (req: >= 5)
Gene RIFs: 923   (req: > 3)
Antibodies: 2725   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 99
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
lifitegrast
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
2
3
0
13.8
99.6
lymphocyte count
3
1
3
85.3
myeloid white cell count
1
1
1
81.3
monocyte count
1
1
1
56.2
leukocyte count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
0
13.8
99.6
lymphocyte count
3
85.3
myeloid white cell count
1
81.3
monocyte count
1
56.2
leukocyte count
1
35
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (45)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cytokine Signaling in Immune system
Extracellular matrix organization
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Protein-Protein Interactions (632)
1 – 10 of 632
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
p_int: 0.999979591
p_ni: 0.000020409
Score: 0.353
Data Source: BioPlex,STRINGDB
GIT1
Tbio
Family: Enzyme
Novelty: 0.01022741
p_int: 0.999938179
p_ni: 0.000061821
Score: 0.473
Data Source: BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty: 0.00919946
p_int: 0.999904171
p_ni: 0.000095829
Score: 0.662
Data Source: BioPlex,STRINGDB
NAT1
Tchem
Family: Enzyme
Novelty: 0.00425955
p_int: 0.999609318
p_ni: 0.000390678
p_wrong: 4e-9
Score: 0.537
Data Source: BioPlex,STRINGDB
ARHGEF6
Tbio
Novelty: 0.02162737
p_int: 0.999498218
p_ni: 0.000501782
Score: 0.777
Data Source: BioPlex,STRINGDB
GIT2
Tbio
Family: Enzyme
Novelty: 0.01530665
p_int: 0.998362758
p_ni: 0.001637242
Score: 0.557
Data Source: BioPlex,STRINGDB
AREG
Tbio
Novelty: 0.0017631
p_int: 0.99816591
p_ni: 0.001447618
p_wrong: 0.000386472
Score: 0.81
Data Source: BioPlex,STRINGDB
EDA2R
Tbio
Novelty: 0.03463669
p_int: 0.996539541
p_ni: 0.003451234
p_wrong: 0.000009225
Score: 0.39
Data Source: BioPlex,STRINGDB
NCS1
Tbio
Novelty: 0.0051468
p_int: 0.993454487
p_ni: 0.006545513
Data Source: BioPlex
NT5C1A
Tbio
Family: Enzyme
Novelty: 0.00634411
p_int: 0.992274969
p_ni: 0.001808786
p_wrong: 0.005916245
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10458.29

PubMed score by year
PubTator Score  5716.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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