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Tbio
EDN1
Endothelin-1

Protein Summary
Description
Endothelins are endothelium-derived vasoconstrictor peptides. This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379375
  • ENSP00000368683
  • ENSG00000078401

Symbol
  • ET1
  • QME
  • PPET1
  • ARCND3
  • HDLCQ7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
PubMedID
1
gene perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15477.05   (req: < 5)
Gene RIFs: 675   (req: <= 3)
Antibodies: 741   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15477.05   (req: >= 5)
Gene RIFs: 675   (req: > 3)
Antibodies: 741   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (466)
EDNRA
Tclin
Family:  GPCR
Novelty:  0.00045591
Score:  0.999
Data Source:  Reactome,STRINGDB
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
Score:  0.999
Data Source:  Reactome,STRINGDB
ECE1
Tchem
Family:  Enzyme
Novelty:  0.00180681
Score:  0.993
Data Source:  Reactome,STRINGDB
EDN2
Tbio
Novelty:  0.00203492
Score:  0.983
Data Source:  STRINGDB
AGT
Tbio
Novelty:  0.00049613
Score:  0.981
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.98
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.975
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.971
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.971
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.97
Data Source:  STRINGDB
Pathways (38)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aortic measurement
3
1
3
69.8
pulse pressure measurement
1
1
1
67.4
hematocrit
3
2
3
60.5
hemoglobin measurement
3
2
3
59
lymphocyte percentage of leukocytes
1
1
1
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aortic measurement
3
69.8
pulse pressure measurement
1
67.4
hematocrit
3
60.5
hemoglobin measurement
3
59
lymphocyte percentage of leukocytes
1
56
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelin 1
VGNC:2773
462437
Mouse
MGI:95283
13614
Rat
RGD:2532
24323
Dog
endothelin 1
VGNC:40199
403424
Horse
endothelin 1
VGNC:17423
100034060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelin 1
Mouse
Rat
Dog
endothelin 1
Horse
endothelin 1
Publication Statistics
PubMed Score 15477.05
PubMed score by year
PubTator Score 5933.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text