You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
IL6
Interleukin-6

Protein Classes
Protein Summary
Description
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258743
  • ENSP00000258743
  • ENSG00000136244
  • ENST00000404625
  • ENSP00000385675

Symbol
  • IFNB2
  • CDF
  • HGF
  • HSF
  • BSF2
  • IL-6
  • BSF-2
  • IFNB2
  • IFN-beta-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
virus perturbation
1
gene perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33962.17   (req: < 5)
Gene RIFs: 3470   (req: <= 3)
Antibodies: 2567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33962.17   (req: >= 5)
Gene RIFs: 3470   (req: > 3)
Antibodies: 2567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (238)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Immune System
Gene Ontology Terms (71)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (1344)
1 – 10 of 1344
IL6R
Tclin
Novelty: 0.00270567
Score: 0.999
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00013496
Score: 0.997
Data Source: Reactome,STRINGDB
IL6ST
Tclin
Novelty: 0.01731532
Score: 0.997
Data Source: Reactome,STRINGDB
IL10
Tbio
Novelty: 0.00007359
Score: 0.997
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00010156
Score: 0.996
Data Source: STRINGDB
SOCS3
Tbio
Novelty: 0.00082008
Score: 0.992
Data Source: Reactome,STRINGDB
IL13
Tbio
Novelty: 0.00043714
Score: 0.988
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.985
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00013623
Score: 0.984
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001974
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  33962.17

PubMed score by year
PubTator Score  26787.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: