Protein Classes
Protein Summary
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induce ...more
- ENST00000258743
- ENSP00000258743
- ENSG00000136244
- ENST00000404625
- ENSP00000385675
- IFNB2
- CDF
- HGF
- HSF
- BSF2
- IL-6
- BSF-2
- IFNB2
- IFN-beta-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
virus perturbation | 1 | ||
gene perturbation | 0.96 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33962.17 (req: < 5)
Gene RIFs: 3470 (req: <= 3)
Antibodies: 2567 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 33962.17 (req: >= 5)
Gene RIFs: 3470 (req: > 3)
Antibodies: 2567 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 67
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (10)
1 – 10 of 10
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (238)
Reactome (21)
KEGG (45)
PathwayCommons (19)
WikiPathways (153)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 21
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Gene Ontology Terms (71)
Functions (3)
Components (4)
Processes (64)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (1344)
1 – 10 of 1344
IL6R
Novelty: 0.00270567
Score: 0.999
Data Source: Reactome,STRINGDB
STAT3
Family: TF
Novelty: 0.00013496
Score: 0.997
Data Source: Reactome,STRINGDB
IL6ST
Novelty: 0.01731532
Score: 0.997
Data Source: Reactome,STRINGDB
IL10
Novelty: 0.00007359
Score: 0.997
Data Source: STRINGDB
IL4
Novelty: 0.00010156
Score: 0.996
Data Source: STRINGDB
SOCS3
Novelty: 0.00082008
Score: 0.992
Data Source: Reactome,STRINGDB
IL13
Novelty: 0.00043714
Score: 0.988
Data Source: STRINGDB
CXCL8
Novelty: 0.00009183
Score: 0.985
Data Source: STRINGDB
JUN
Family: TF
Novelty: 0.00013623
Score: 0.984
Data Source: STRINGDB
TNF
Novelty: 0.00001974
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score 33962.17
PubMed score by year
PubTator Score 26787.89
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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