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Tchem
FGF1
Fibroblast growth factor 1

Protein Summary
Description
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and ar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337706
  • ENSP00000338548
  • ENSG00000113578
  • ENST00000359370
  • ENSP00000352329
  • ENST00000360966
  • ENSP00000354231
  • ENST00000378046
  • ENSP00000367285
  • ENST00000419524
  • ENSP00000396195
  • ENST00000441680
  • ENSP00000404742
  • ENST00000610990
  • ENSP00000481868
  • ENST00000612258
  • ENSP00000479024
  • ENST00000619447
  • ENSP00000480980
  • ENST00000621536
  • ENSP00000480791

Symbol
  • FGFA
  • AFGF
  • ECGF
  • FGFA
  • ECGFA
  • ECGFB
  • FGF-1
  • HBGF1
  • HBGF-1
  • GLIO703
  • ECGF-beta
  • FGF-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
disease perturbation
0.95
PubMedID
0.93
biological term
0.89
gene perturbation
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1798.99   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 684   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1798.99   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 684   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
80.1
heel bone mineral density
2
2
2
76.5
bone density
1
1
1
66.7
waist-hip ratio
2
2
2
62.3
viral load
1
1
1
58.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
80.1
heel bone mineral density
2
76.5
bone density
1
66.7
waist-hip ratio
2
62.3
viral load
1
58.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 1
VGNC:6875
462158
Mouse
MGI:95515
14164
Rat
RGD:2605
25317
Dog
fibroblast growth factor 1
VGNC:52134
607724
Horse
fibroblast growth factor 1
VGNC:18008
100033960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 1
Mouse
Rat
Dog
fibroblast growth factor 1
Horse
fibroblast growth factor 1
Protein Data Bank (97)
1 – 5 of 97
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (105)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 76
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (45)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (220)
1 – 10 of 220
GPC1
Tbio
Novelty: 0.00293087
p_int: 0.999973568
p_ni: 0.000026428
p_wrong: 4e-9
Score: 0.455
Data Source: BioPlex,STRINGDB
GSE1
Tdark
Novelty: 0.04331197
p_int: 0.999946208
p_ni: 0.000053791
Score: 0.795
Data Source: BioPlex,STRINGDB
SDC4
Tbio
Novelty: 0.00319073
p_int: 0.999914402
p_ni: 0.000037481
p_wrong: 0.000048117
Score: 0.634
Data Source: BioPlex,STRINGDB
TGFBR3
Tbio
Novelty: 0.0077307
p_int: 0.99907326
p_ni: 0.000926737
p_wrong: 4e-9
Score: 0.26
Data Source: BioPlex,STRINGDB
EGFLAM
Tbio
Novelty: 0.02955802
p_int: 0.998554615
p_ni: 0.000002514
p_wrong: 0.001442871
Score: 0.656
Data Source: BioPlex,STRINGDB
HMG20A
Tbio
Family: TF
Novelty: 0.11994252
p_int: 0.998443369
p_ni: 0.000243516
p_wrong: 0.001313115
Score: 0.32
Data Source: BioPlex,STRINGDB
CLDN10
Tbio
Novelty: 0.02175843
p_int: 0.99819635
p_ni: 0.001793078
p_wrong: 0.000010572
Score: 0.269
Data Source: BioPlex,STRINGDB
GPC3
Tbio
Novelty: 0.00151823
p_int: 0.978083903
p_ni: 0.007754437
p_wrong: 0.01416166
Score: 0.349
Data Source: BioPlex,STRINGDB
SDC2
Tbio
Novelty: 0.00597758
p_int: 0.944272046
p_ni: 0.000113641
p_wrong: 0.055614313
Score: 0.362
Data Source: BioPlex,STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1798.99

PubMed score by year
PubTator Score  783.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer