Tbio HMGN2 Non-histone chromosomal protein HMG-17

Protein Summary

Description

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P05204
• Q0VGD5
• Q6FGI5
• Q96C64

Gene Name

• HMGN2

Ensembl ID

• ENST00000361427
• ENSP00000355228
• ENSG00000198830
• ENST00000619352
• ENSP00000481160

Symbol

• HMG17
• HMG17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
histone modification site profile	0.88
transcription factor binding site profile	0.85
virus perturbation	0.83
transcription factor	0.81

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Non-histone Chromosomal Protein Hmg-17

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Non-histone Chromosomal Protein Hmg-17

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.52   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 270   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.52   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (30)

Explore Interacting Targets

1 – 10 of 30

• See Interactions on String-DB

KLHL36

Tdark

Novelty:  1.4153425

p_int:  0.999999432

p_ni:  5.68e-7

Score:  0.19

Data Source:  BioPlex,STRINGDB

PARP2

Tclin

Family:  Enzyme

Novelty:  0.00545618

p_int:  0.9967925

p_ni:  0.0032075

Score:  0.197

Data Source:  BioPlex,STRINGDB

CHMP1A

Tbio

Novelty:  0.03969333

p_int:  0.986940777

p_ni:  0.013057815

p_wrong:  0.000001409

Score:  0.189

Data Source:  BioPlex,STRINGDB

H2AFY

Tbio

Novelty:  0.01150729

p_int:  0.870485399

p_ni:  0.129453665

p_wrong:  0.000060935

Score:  0.163

Data Source:  BioPlex,STRINGDB

PYGB

Tchem

Family:  Enzyme

Novelty:  0.00224148

p_int:  0.865531273

p_ni:  0.134468727

Score:  0.209

Data Source:  BioPlex,STRINGDB

GBE1

Tbio

Family:  Enzyme

Novelty:  0.00233237

p_int:  0.846705848

p_ni:  0.153294152

Score:  0.332

Data Source:  BioPlex,STRINGDB

HIST1H2AG

Tbio

Novelty:  0.03331195

p_int:  0.776402775

p_ni:  0.223597225

Score:  0.207

Data Source:  BioPlex,STRINGDB

HMGN1

Tbio

Novelty:  0.00492501

Score:  0.96

Data Source:  STRINGDB

HMGN5

Tbio

Novelty:  0.0296146

Score:  0.905

Data Source:  STRINGDB

TRMT5

Tbio

Family:  Enzyme

Novelty:  0.02509765

Score:  0.772

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

PathwayCommons (2)

Find Similar Targets

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5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	Prolactin	104 targets	PathwayCommons: netpath
PathwayCommons: netpath	TSH	81 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
Prolactin	104 targets	PathwayCommons: netpath
TSH	81 targets	PathwayCommons: netpath

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (2)

Components (4)

Processes (2)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
nucleosomal DNA binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1	1	1		81.1
lymphocyte count	EFO_0004587	2	2	2		79.4
appendicular lean mass	EFO_0004980	2	1	2		78.9
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		71.5
forced expiratory volume	EFO_0004314	1	2	2		66.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1		81.1
lymphocyte count	EFO_0004587	2		79.4
appendicular lean mass	EFO_0004980	2		78.9
mean corpuscular hemoglobin concentration	EFO_0004528	1		71.5
forced expiratory volume	EFO_0004314	2		66.6

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
ADP-ribosylation
Complete proteome
Cytoplasm
Direct protein sequencing
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
body height
C-reactive protein measurement
fasting blood glucose measurement
forced expiratory volume
IGF-1 measurement
leukocyte count
lymphocyte count
mean corpuscular hemoglobin concentration
mean corpuscular volume

MGI Phenotype Find Similar Targets

No Header	No Header
craniofacial phenotype
embryo phenotype
growth/size/body region phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	high mobility group nucleosomal binding domain 2	VGNC:1262	737435
Mouse	high mobility group nucleosomal binding domain 2	MGI:96136	15331
Rat	high mobility group nucleosomal binding domain 2	RGD:620649	114637
Dog	high mobility group nucleosomal binding domain 2		403686
Pig	high mobility group nucleosomal binding domain 2		100524500

Species	Name	OMA	EggNOG	Inparanoid
Chimp	high mobility group nucleosomal binding domain 2
Mouse	high mobility group nucleosomal binding domain 2
Rat	high mobility group nucleosomal binding domain 2
Dog	high mobility group nucleosomal binding domain 2
Pig	high mobility group nucleosomal binding domain 2

Publication Statistics

PubMed Score 125.52

PubMed score by year

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PubTator Score 104.84

PubTator score by year

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Related Publications

Text Mined References (40)

GeneRif Annotations (20)

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10

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PMID	Year	Title