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Tbio
HMGN2
Non-histone chromosomal protein HMG-17

Protein Summary
Description
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity). The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361427
  • ENSP00000355228
  • ENSG00000198830
  • ENST00000619352
  • ENSP00000481160

Symbol
  • HMG17
  • HMG17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
histone modification site profile
0.88
transcription factor binding site profile
0.85
virus perturbation
0.83
transcription factor
0.81


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.52   (req: < 5)
View Publications
Gene RIFs: 20   (req: <= 3)
View Gene RIFs
Antibodies: 270   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.52   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
high mobility group nucleosomal binding domain 2
VGNC:1262
737435
Mouse
high mobility group nucleosomal binding domain 2
MGI:96136
15331
Rat
high mobility group nucleosomal binding domain 2
RGD:620649
114637
Dog
high mobility group nucleosomal binding domain 2
403686
Pig
high mobility group nucleosomal binding domain 2
100524500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
high mobility group nucleosomal binding domain 2
Mouse
high mobility group nucleosomal binding domain 2
Rat
high mobility group nucleosomal binding domain 2
Dog
high mobility group nucleosomal binding domain 2
Pig
high mobility group nucleosomal binding domain 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P05204-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
RNA binding
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
nucleosomal DNA binding
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (30)
1 – 10 of 30
KLHL36
Tdark
Novelty: 1.4153425
p_int: 0.999999432
p_ni: 5.68e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00545618
p_int: 0.9967925
p_ni: 0.0032075
Score: 0.197
Data Source: BioPlex,STRINGDB
CHMP1A
Tbio
Novelty: 0.03969333
p_int: 0.986940777
p_ni: 0.013057815
p_wrong: 0.000001409
Score: 0.189
Data Source: BioPlex,STRINGDB
H2AFY
Tbio
Novelty: 0.01150729
p_int: 0.870485399
p_ni: 0.129453665
p_wrong: 0.000060935
Score: 0.163
Data Source: BioPlex,STRINGDB
PYGB
Tbio
Family: Enzyme
Novelty: 0.00224148
p_int: 0.865531273
p_ni: 0.134468727
Score: 0.209
Data Source: BioPlex,STRINGDB
GBE1
Tbio
Family: Enzyme
Novelty: 0.00233237
p_int: 0.846705848
p_ni: 0.153294152
Score: 0.332
Data Source: BioPlex,STRINGDB
HIST1H2AG
Tbio
Novelty: 0.03331195
p_int: 0.776402775
p_ni: 0.223597225
Score: 0.207
Data Source: BioPlex,STRINGDB
HMGN1
Tbio
Novelty: 0.00492501
Score: 0.96
Data Source: STRINGDB
HMGN5
Tbio
Novelty: 0.0296146
Score: 0.905
Data Source: STRINGDB
TRMT5
Tbio
Family: Enzyme
Novelty: 0.02509765
Score: 0.772
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.52

PubMed score by year
PubTator Score  104.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer