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Tbio
EIF2S1
Eukaryotic translation initiation factor 2 subunit 1

Protein Summary
Description
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of form ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256383
  • ENSP00000256383
  • ENSG00000134001
  • ENST00000466499
  • ENSP00000425299

Symbol
  • EIF2A
  • EIF2
  • EIF-2
  • EIF2A
  • EIF-2A
  • EIF-2alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
kinase
0.92
virus perturbation
0.88
biological term
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1290.23   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 804   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1290.23   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Formation of the ternary complex, and subsequently, the 43S complex
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Formation of the ternary complex, and subsequently, the 43S complex
Gene Ontology Terms (32)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (364)
1 – 10 of 364
EIF2S2
Tbio
Novelty: 0.0146918
p_int: 0.99980766
p_ni: 0.00019234
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
EIF2AK4
Tchem
Family: Kinase
Novelty: 0.00241683
Score: 0.999
Data Source: STRINGDB
RPS8
Tbio
Novelty: 0.00976281
Score: 0.999
Data Source: STRINGDB
EIF3B
Tbio
Novelty: 0.00889042
Score: 0.999
Data Source: STRINGDB
RPS4X
Tbio
Novelty: 0.01396038
Score: 0.999
Data Source: STRINGDB
EIF2S3
Tbio
Novelty: 0.02055484
Score: 0.999
Data Source: Reactome,STRINGDB
RPS3
Tbio
Novelty: 0.003106
Score: 0.998
Data Source: STRINGDB
EIF2AK1
Tchem
Family: Kinase
Novelty: 0.01207075
Score: 0.998
Data Source: STRINGDB
RPS6
Tbio
Novelty: 0.00122241
Score: 0.998
Data Source: STRINGDB
RPS12
Tbio
Novelty: 0.00497802
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  1290.23

PubMed score by year
PubTator Score  442.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer