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Tchem
ALPL
Alkaline phosphatase, tissue-nonspecific isozyme

Protein Summary
Description
This isozyme may play a role in skeletal mineralization. This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374832
  • ENSP00000363965
  • ENSG00000162551
  • ENST00000374840
  • ENSP00000363973
  • ENST00000539907
  • ENSP00000437674
  • ENST00000540617
  • ENSP00000442672

Symbol
  • HOPS
  • TNAP
  • TNALP
  • APTNAP
  • TNSALP
  • AP-TNAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.91
chemical
0.87
phenotype
0.85
PubMedID
0.79
transcription factor binding site profile
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 785.11   (req: < 5)
Gene RIFs: 200   (req: <= 3)
Antibodies: 934   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 785.11   (req: >= 5)
Gene RIFs: 200   (req: > 3)
Antibodies: 934   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 116
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0