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Tchem
CYP2E1
Cytochrome P450 2E1

Protein Summary
Description
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252945
  • ENSP00000252945
  • ENSG00000130649
  • ENST00000463117
  • ENSP00000440689

Symbol
  • CYP2E
  • CPE1
  • CYP2E
  • P450-J
  • P450C2E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
co-expressed gene
1
drug
1
disease
0.85
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3516.72   (req: < 5)
Gene RIFs: 347   (req: <= 3)
Antibodies: 576   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3516.72   (req: >= 5)
Gene RIFs: 347   (req: > 3)
Antibodies: 576   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (11)
Protein-Protein Interactions (197)
RMDN1
Tdark
Novelty:  1.28615984
p_int:  0.999853696
p_ni:  0.000142991
p_wrong:  0.000003313
Score:  0.685
Data Source:  BioPlex,STRINGDB
POLR3E
Tbio
Family:  Enzyme
Novelty:  0.06500715
p_int:  0.954550085
p_ni:  0.045449915
Score:  0.237
Data Source:  BioPlex,STRINGDB
ADH1B
Tclin
Family:  Enzyme
Novelty:  0.00204308
Score:  0.974
Data Source:  STRINGDB
ADH1C
Tclin
Family:  Enzyme
Novelty:  0.00507607
Score:  0.974
Data Source:  STRINGDB
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
Score:  0.974
Data Source:  STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.973
Data Source:  STRINGDB
NAT2
Tbio
Family:  Enzyme
Novelty:  0.00150849
Score:  0.966
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.964
Data Source:  STRINGDB
ADH1A
Tclin
Family:  Enzyme
Novelty:  0.00199598
Score:  0.962
Data Source:  STRINGDB
ADH4
Tbio
Family:  Enzyme
Novelty:  0.00358463
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets (11)
Explore Nearest Tclin Targets
1 – 2 of 2
Pathways (39)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of maresin-like SPMs
Reactome
Biosynthesis of maresins
Reactome
Biosynthesis of specialized proresolving mediators (SPMs)
Name
Explore in Pharos
Explore in Source
Biological oxidations
Biosynthesis of DHA-derived SPMs
Biosynthesis of maresin-like SPMs
Biosynthesis of maresins
Biosynthesis of specialized proresolving mediators (SPMs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tea consumption measurement
1
1
1
62.1
coffee consumption measurement
2
1
2
62.1
body mass index
1
1
0
5.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tea consumption measurement
1
62.1
coffee consumption measurement
2
62.1
body mass index
0
5.1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 2 subfamily E member 1
VGNC:6152
450857
Mouse
MGI:88607
13106
Rat
RGD:2475
25086
Dog
cytochrome P450 family 2 subfamily E member 1
VGNC:50353
415128
Horse
cytochrome P450 family 2 subfamily E member 1
VGNC:50568
100066422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 2 subfamily E member 1
Mouse
Rat
Dog
cytochrome P450 family 2 subfamily E member 1
Horse
cytochrome P450 family 2 subfamily E member 1
Publication Statistics
PubMed Score 3516.72
PubMed score by year
PubTator Score 1376.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title