Protein Summary
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
- ENST00000252945
- ENSP00000252945
- ENSG00000130649
- ENST00000463117
- ENSP00000440689
- CYP2E
- CPE1
- CYP2E
- P450-J
- P450C2E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
co-expressed gene | 1 | ||
drug | 1 | ||
disease | 0.85 | ||
disease perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3516.72 (req: < 5)
Gene RIFs: 347 (req: <= 3)
Antibodies: 576 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3516.72 (req: >= 5)
Gene RIFs: 347 (req: > 3)
Antibodies: 576 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (11)
Protein-Protein Interactions (197)
RMDN1
Novelty: 1.28615984
p_int: 0.999853696
p_ni: 0.000142991
p_wrong: 0.000003313
Score: 0.685
Data Source: BioPlex,STRINGDB
POLR3E
Family: Enzyme
Novelty: 0.06500715
p_int: 0.954550085
p_ni: 0.045449915
Score: 0.237
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (11)
Upstream (2)
Downstream (9)
1 – 2 of 2
Pathways (39)
Reactome (11)
KEGG (9)
PathwayCommons (3)
WikiPathways (16)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Biosynthesis of DHA-derived SPMs | ||||
Reactome | Biosynthesis of maresin-like SPMs | ||||
Reactome | Biosynthesis of maresins | ||||
Reactome | Biosynthesis of specialized proresolving mediators (SPMs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Biosynthesis of DHA-derived SPMs | ||||
Biosynthesis of maresin-like SPMs | ||||
Biosynthesis of maresins | ||||
Biosynthesis of specialized proresolving mediators (SPMs) | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (10)
Components (6)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
tea consumption measurement | 1 | 1 | 1 | 62.1 | |||||
coffee consumption measurement | 2 | 1 | 2 | 62.1 | |||||
body mass index | 1 | 1 | 0 | 5.1 | 17.8 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
tea consumption measurement | 1 | 62.1 | |||||
coffee consumption measurement | 2 | 62.1 | |||||
body mass index | 0 | 5.1 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 2 subfamily E member 1 | VGNC:6152 | 450857 | |||||
Mouse | MGI:88607 | 13106 | ||||||
Rat | RGD:2475 | 25086 | ||||||
Dog | cytochrome P450 family 2 subfamily E member 1 | VGNC:50353 | 415128 | |||||
Horse | cytochrome P450 family 2 subfamily E member 1 | VGNC:50568 | 100066422 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 2 subfamily E member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 2 subfamily E member 1 | |||||
Horse | cytochrome P450 family 2 subfamily E member 1 | |||||
Publication Statistics
PubMed Score 3516.72
PubMed score by year
PubTator Score 1376.19
PubTator score by year
Related Publications
Text Mined References (623)
GeneRif Annotations (347)
Items per page:
0 of 0
PMID | Year | Title |
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