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Tbio
PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

Protein Summary
Description
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376279
  • ENSP00000365456
  • ENSG00000175198
  • ENST00000376285
  • ENSP00000365462
  • ENST00000376286
  • ENSP00000365463
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
histone modification site profile
0.89
transcription factor perturbation
0.88
trait
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.27   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.27   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
PCCB
Tbio
Family:  Enzyme
Novelty:  0.01085161
p_int:  0.99521455
p_ni:  0.000326249
p_wrong:  0.004459201
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ICMT
Tchem
Family:  Enzyme
Novelty:  0.00706181
p_int:  0.971436672
p_ni:  0.028562764
p_wrong:  5.65e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
ACSM5
Tbio
Family:  Enzyme
Novelty:  0.11562771
p_int:  0.95938715
p_ni:  0.040612242
p_wrong:  6.08e-7
Score:  0.248
Data Source:  BioPlex,STRINGDB
TTC1
Tbio
Novelty:  0.01389711
p_int:  0.871506359
p_ni:  0.128493633
p_wrong:  8e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.815531314
p_ni:  0.184410763
p_wrong:  0.000057923
Data Source:  BioPlex
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.815324867
p_ni:  0.18400735
p_wrong:  0.000667783
Data Source:  BioPlex
RARS2
Tbio
Family:  Enzyme
Novelty:  0.01185296
p_int:  0.787335771
p_ni:  0.212663755
p_wrong:  4.74e-7
Score:  0.201
Data Source:  BioPlex,STRINGDB
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.787235479
p_ni:  0.212764036
p_wrong:  4.85e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.782534873
p_ni:  0.217461426
p_wrong:  0.000003702
Score:  0.152
Data Source:  BioPlex,STRINGDB
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.754187289
p_ni:  0.245806217
p_wrong:  0.000006494
Data Source:  BioPlex
Pathways (23)
Biotin transport and metabolism (R-HSA-196780)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biotin transport and metabolism
Reactome
Defective HLCS causes multiple carboxylase deficiency
Reactome
Defects in biotin (Btn) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Biotin transport and metabolism
Defective HLCS causes multiple carboxylase deficiency
Defects in biotin (Btn) metabolism
Defects in vitamin and cofactor metabolism
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
4
2
7.4
91.2
Myopia
2
3
0
6.3
88.8
smoking status measurement
3
5
4
1
87.4
age at onset
1
2
0
7.4
80
self reported educational attainment
1
2
2
67.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
7.4
91.2
Myopia
0
6.3
88.8
smoking status measurement
4
1
87.4
age at onset
0
7.4
80
self reported educational attainment
2
67.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
propionyl-CoA carboxylase subunit alpha
VGNC:5088
738775
Macaque
propionyl-CoA carboxylase alpha subunit
699844
Mouse
MGI:97499
110821
Rat
RGD:3264
687008
Dog
propionyl-CoA carboxylase subunit alpha
VGNC:44292
476975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
propionyl-CoA carboxylase subunit alpha
Macaque
propionyl-CoA carboxylase alpha subunit
Mouse
Rat
Dog
propionyl-CoA carboxylase subunit alpha
Publication Statistics
PubMed Score 194.27
PubMed score by year
PubTator Score 89.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title