PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial
Protein Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
- ENST00000376279
- ENSP00000365456
- ENSG00000175198
- ENST00000376285
- ENSP00000365462
- ENST00000376286
- ENSP00000365463
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
histone modification site profile | 0.89 | ||
transcription factor perturbation | 0.88 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 267.46 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 174 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 267.46 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 174 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0